现代医药卫生2025，Vol.41Issue(3)：616-620,5.DOI:10.3969/j.issn.1009-5519.2025.03.009
血清CysC联合TSH、FT3、FT4检测对2型糖尿病患者早期肾脏损伤的诊断价值
Diagnostic value of serum CysC combined with TSH,FT3 and FT4 levels in early renal injury in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To evaluate the diagnostic value of serum cystatin C(CysC)combined with thy-roid stimulating hormone(TSH),free triiodothyronine(FT3)and free thyroxine(FT4)in early renal injury in patients with type 2 diabetes mellitus(T2DM).Methods A total of 190 patients with T2DM admitted to our hospital from January 2023 to January 2024 were selected as the research objects.According to the results of pathological examination,they were divided into the renal injury group(86 cases)and the non-renal injury group(104 cases).The levels of serum CysC,TSH,FT3 and FT4 were detected in the two groups.The receiv-er operating characteristic(ROC)curve was used to analyze the diagnostic value of serum CysC combined with TSH,FT3 and FT4 in early renal injury in patients with T2DM.Spearman rank correlation coefficient was used to analyze the correlation between serum CysC combined with TSH,FT3,FT4 levels and the severi-ty of renal injury.Results The proportion of patients with a history of hypertension in the renal injury group was significantly higher than that in the non-renal injury group,the serum CysC and TSH levels were signifi-cantly higher than those in the non-renal injury group,and the FT3 and FT4 levels were significantly lower than those in the non-renal injury group,with statistically significant differences(P<0.05).The risk of renal injury was related to the history of hypertension,the increase of serum CysC and TSH levels,and the decrease of FT3 and FT4 levels(P<0.05).The area under the ROC curve of serum CysC combined with TSH,FT3 and FT4 in the diagnosis of renal injury was 0.789,and the area under the ROC curve of each single diagnosis of renal injury was 0.629,0.666,0.654 and 0.683,respectively.The diagnostic value of combined detection was significantly higher than that of each single detection,and the difference was statistically significant(P<0.05).Serum CysC and TSH levels were positively correlated with the severity of renal injury(r=0.244,0.289,P<0.001,<0.001),while FT3 and FT4 levels were negatively correlated with the severity of renal in-jury(r=-0.284,-0.316,P<0.001,<0.001).Conclusion The levels of serum CysC,TSH,FT3 and FT4 are correlated with the occurrence of renal injury in patients with T2DM,which has important diagnostic value for early renal injury.关键词
血清CysC/促甲状腺激素/游离三碘甲状腺原氨酸/游离甲状腺素/2型糖尿病/肾脏损伤/诊断价值Key words
Serum CysC/Thyroid stimulating hormone/Free triiodothyronine/Free thyroxine/Type 2 diabetes/Renal injury/Diagnostic value分类
临床医学引用本文复制引用
水应兰,陈众,常青..血清CysC联合TSH、FT3、FT4检测对2型糖尿病患者早期肾脏损伤的诊断价值[J].现代医药卫生,2025,41(3):616-620,5.基金项目
河南省医学科技攻关计划项目(LHGJ20220491). （LHGJ20220491）
