现代医药卫生2025，Vol.41Issue(3)：621-624,4.DOI:10.3969/j.issn.1009-5519.2025.03.010
参麦注射液对冠脉造影后急性肾损伤炎症因子的影响
Effect of Shenmai injection on inflammatory factors in acute kidney injury after coronary angiography
摘要
Abstract
Objective To investigate the effect of Shenmai injection on inflammatory factors in acute kidney injury(AKI)after coronary angiography.Methods A total of 80 patients who were scheduled for cor-onary angiography at the Department of Cardiovascular Medicine,the hospital from November 2021 to August 2024 were selected as the study subjects.They were randomly divided into an observation group and a control group,with 40 cases in each group.Both groups received conventional symptomatic treatment.The observa-tion group was additionally treated with Shenmai injection,and both groups were observed for three days after coronary angiography.The incidence of acute kidney injury after coronary angiography,renal function indica-tors[blood urea nitrogen(BUN),serum creatinine(Scr),cystatin C(CysC)],renal hemodynamic parameters[peak systolic flow velocity(PSFV),end-diastolic flow velocity(EDFV),resistance index(RI],and inflamma-tory markers[interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]were compared be-tween the two groups.Results The incidence of acute kidney injury after coronary angiography in the obser-vation group[12.5%(5/40)]was significantly lower than that in the control group[40.0%(16/40)],with a statistically significant difference(χ2=7.812,P=0.005).The PSFV and EDFV levels in the observation group on the 3rd day after surgery[(33.61±4.39),(12.39±1.43)cm/s]were higher than those in the con-trol group[(29.23±4.51),(9.46±1.67)cm/s],with statistically significant differences(P<0.05).The lev-els of IL-6,IL-8,and TNF-α in the observation group on the 3rd day after surgery[(24.61±1.53),(6.31±0.82),(6.84±1.24)pg/mL]were lower than those in the control group[(26.37±1.82),(8.14±1.13),(8.17±1.30)pg/mL],with statistically significant differences(P<0.05).Conclusion Shenmai injection can reduce the incidence of acute kidney injury after coronary angiography,improve renal hemodynamic parameters after angiography,promote the recovery of renal function,and alleviate the inflammatory response in the body.关键词
参麦注射液/血管造影术/造影剂/急性肾损伤/炎症因子Key words
Shenmai injection/Angiography/Contrast agent/Acute kidney injury/Inflamma-tory factors分类
中医学引用本文复制引用
崔冰,赵安社,陈鹏,李海涛..参麦注射液对冠脉造影后急性肾损伤炎症因子的影响[J].现代医药卫生,2025,41(3):621-624,4.基金项目
河南省中医药科学研究专项课题项目(20-21ZY2096). （20-21ZY2096）
