现代医药卫生2025，Vol.41Issue(3)：653-656,4.DOI:10.3969/j.issn.1009-5519.2025.03.018
靶向二代测序技术早期诊断鹦鹉热衣原体重症肺炎1例并文献复习
Early diagnosis of chlamydia psittaci severe pneumonia by targeted next-generation sequencing technology:a case report and literature review
王栋 1李炼 1颜新生1
作者信息
- 1. 武汉亚心总医院/武汉科技大学附属武汉亚心总医院医学检验科,湖北 武汉 430056
- 折叠
摘要
Abstract
In February 2023,a patient with severe chlamydia psittaci pneumonia diagnosed by targeted next-generation sequencing(tNGS)was admitted to the Department of Respiratory and Critical Care Medicine of the hospital.He was admitted to the hospital due to chills,fever,headache for seven days,chest tightness and wheezing for two days.The initial diagnosis was considered severe pneumonia and acute respiratory fail-ure.The cause of severe pneumonia has not been identified after comprehensive laboratory and imaging exami-nations.The tNGS technique was used to detect Chlamydia psittaci(757 sequences)in bronchoalveolar lavage fluid samples of patients,and the time from admission to diagnosis was only three days.After the pathogen was determined,the antibacterial drugs were adjusted in time,and moxifloxacin was used to obtain good cura-tive effect.Chlamydia psittaci infection can lead to severe pneumonia and acute respiratory failure in humans.Due to the non-specific clinical manifestations and the limitations of traditional etiological detection methods,early diagnosis is challenging and treatment is not timely.As a rapid,accurate and economical diagnostic meth-od for pathogenic microorganisms,tNGS technology is of great value in the early diagnosis of severe pneumo-nia with unknown pathogens.关键词
鹦鹉热衣原体/危重病/肺炎/靶向二代测序/早期诊断/病例报告Key words
Chlamydia psittaci/Critical illness/Pneumonia/Targeted next-generation sequen-cing/Early diagnosis/Case report分类
医药卫生引用本文复制引用
王栋,李炼,颜新生..靶向二代测序技术早期诊断鹦鹉热衣原体重症肺炎1例并文献复习[J].现代医药卫生,2025,41(3):653-656,4.
