现代医药卫生2025，Vol.41Issue(3)：753-757,5.DOI:10.3969/j.issn.1009-5519.2025.03.039
孟德尔随机化方法在医学影像学中的应用研究进展
Research progress on the application of Mendelian randomization method in medical imaging
摘要
Abstract
Mendelian randomization(MR)is a statistical method that uses genetic variation as instru-mental variables to explore the causal relationship between exposure factors and research outcomes,which can effectively eliminate the interference of confounding factors and reverse causality.In recent years,with the de-velopment of Genome-Wide association studies and the publication of a large number of aggregated data sets,the MR method has been applied in various fields of medicine.In this paper,the principle of MR and its appli-cation in medical imaging are summarized,and the opportunities and challenges in the field of medical imaging are discussed by comparing with randomized controlled trials,in order to promote the application of MR in the field of medical imaging.关键词
孟德尔随机化/医学影像学/单核苷酸多态性/全基因组关联研究/综述Key words
Mendelian randomization/Medical imaging/Single nucleotide polymorphism/Ge-nome-wide association study/Review分类
医药卫生引用本文复制引用
黄可玲,华媚琦,叶瑾璇,徐正男,张振煜,王文卓,吴林玉,高晨..孟德尔随机化方法在医学影像学中的应用研究进展[J].现代医药卫生,2025,41(3):753-757,5.基金项目
浙江省医药卫生科技计划项目(2024KY129 （）
2024KY132 （）
2022KY230) （）
浙江中医药大学校级科研项目(2022JKJNTZ19). （2022JKJNTZ19）
