现代医药卫生2025，Vol.41Issue(3)：776-778,3.DOI:10.3969/j.issn.1009-5519.2025.03.044
不同来源间充质干细胞对自然杀伤细胞的影响
Effects of mesenchymal stem cells from different sources on natural killer cells
刘秀丽 1王洪波 1谢鹏 1江明1
作者信息
- 1. 新疆医科大学第一附属医院血液病科,新疆 乌鲁木齐 830000
- 折叠
摘要
Abstract
The ability of mesenchymal stem cells(MSCs)to inhibit T lymphocytes promotes their use in the treatment of graft-versus-host disease.Since MSC can also regulate the activity of natural killer(NK)cells,NK cells play an important role in graft-versus-leukemia response.Therefore,the treatment of mesen-chymal stem cells after transplantation or the prevention of graft-versus-host disease may also affect the anti-leukemia effect of NK cells.MSC can be amplified from a variety of sources,especially bone marrow and fat,but it is not clear whether the cell source has an effect on its immune regulation ability.This article reviews the immunomodulatory effects of MSC from different sources on NK cells to determine which source of MSC is more conducive to protecting NK cell activity and thus protecting graft anti-leukemia effects.关键词
间充质干细胞/自然杀伤细胞/综述Key words
Mesenchymal stem cells/Natural killer cells/Review分类
医药卫生引用本文复制引用
刘秀丽,王洪波,谢鹏,江明..不同来源间充质干细胞对自然杀伤细胞的影响[J].现代医药卫生,2025,41(3):776-778,3.
