新发传染病电子杂志2025，Vol.10Issue(1)：12-16,5.DOI:10.19871/j.cnki.xfcrbzz.2025.01.003
南昌市两县区2004-2022年报告丙型肝炎确诊病例HCV RNA持续阳性结果及影响因素分析
Analysis of HCV RNA persistent positive results and influencing factors in reported Hepatitis C cases from two counties of Nanchang,2004-2022
摘要
Abstract
Objective To understand the current infection status of reported hepatitis C(HCV)confirmed cases in two counties Nanchang from 2004 to 2022,and to analyze the factors related to the persistence of HCV RNA positivity and to provide scientific basis for the elimination of hepatitis C.Method A cluster sampling method was used to select two districts with the highest number of previously reported HCV cases from nine counties/districts in Nanchang as study sites.Data on HCV confirmed cases from 2004 to 2022 were downloaded from the Chinese Center for Disease Control and Prevention Information System.After a thorough review and organization of the database,on-site questionnaire surveys were conducted to analyze the current status of antiviral treatment.Logistic regression analysis was used to identify factors associated with persistent HCV RNA positivity.Result A total of 510 previously confirmed HCV cases were surveyed,with 505 valid questionnaires(99.02%)returned.The rate of persistent HCV RNA positivity was 30.89%,and the rate of antiviral treatment was 24.55%.Multivariate logistic regression analysis showed that male gender(OR=2.041,95%CI:1.332-3.127)personal monthly income＜3000 yuan(OR=2.121,95%CI:1.358-3.312)and comorbid diabetes(OR=2.246,95%CI:1.153-4.377)were risk factors for persistent HCV RNA positivity.While awareness of hepatitis C knowledge(OR=0.384,95%CI:0.249-0.592)and having received antiviral treatment(OR=0.186,95%CI:0.101-0.342)were protective factors.The cure rate of direct-acting antivirals(DAAs)treatment regimen was higher than that of interferon(IFN)combined with ribavirin treatment regimen(χ2=11.246,P=0.004).Conclusion The rate of persistent HCV RNA positivity among previously reported HCV cases from two counties of Nanchang remains high.It is imperative to enhance health education on hepatitis C prevention,expand treatment coverage,and ultimately aim for the elimination of hepatitis C as a public health threat.关键词
丙型肝炎/丙型肝炎病毒核糖核酸/抗病毒治疗/影响因素Key words
Hepatitis C/Hepatitis C virus RNA/Antiviral treatment/Influencing factors分类
医药卫生引用本文复制引用
涂志斌,莫佳丽,路亮,全凯锋,周亚岚,况杰,周显凤,冯长华,邱丽萍,童小琴..南昌市两县区2004-2022年报告丙型肝炎确诊病例HCV RNA持续阳性结果及影响因素分析[J].新发传染病电子杂志,2025,10(1):12-16,5.基金项目
1.江西省自然科学基金(20242BAB25355) （20242BAB25355）
2江西省卫健委普通科技计划项目(202510757和202410613) （202510757和202410613）
3.南昌市疾病预防控制中心横向合作项目(NCCDC202304) （NCCDC202304）
