心脑血管病防治2025，Vol.25Issue(2)：27-31,5.DOI:10.3969/j.issn.1009-816x.2025.02.006
胎球蛋白A和铁蛋白表达与冠状动脉慢血流的相关性
Correlation of alpha-2-heremans-schmid glycoprotein and serum ferritin expression with coronary slow flow
摘要
Abstract
Objective To study the correlation between the expression of alpha-2-heremans-schmid glycoprotein(AHSG)and serum ferritin(SF)and coronary slow flow in patients with coronary heart disease.Methods A retrospective analysis on 120 patients with coronary heart disease admitted to the Second Affiliated Hospital of Xingtai Medical College from January 2020 to February 2023 was performed.Coronary angiography was performed,and patients were classified into the coronary slow flow group and the control group based on the thrombolysis in myocardial infarction(TIMI)frame count method,with TIMI frame count>20 frames indicating coronary slow flow.Serum levels of AHSG and SF of the two groups were mearsured at admission.A correlation analysis of the relationship between serum AHSG and SF with TIMI frame count was conducted.Multivariate Logistic regression analysis was used to determine factors influencing coronary slow flow.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive value of serum AHSG and SF for coronary slow flow.Results The coronary slow flow group had significantly lower serum AHSG and higher SF levels compared to the control group(t=16.373,8.825;P<0.01).The TIMI frame count was(27.31±3.04)frames in the coronary slow flow group and(10.25±1.54)frames in the control group.Serum AHSG was negatively correlated with TIMI frame count(r=-0.762,P<0.01),while serum SF was positively correlated with TIMI frame count(r=0.748,P<0.01).Logistic regression analysis indicated that AHSG and SF were factors influencing coronary slow flow(OR=0.554,2.184;P<0.05).ROC curve analysis showed that the critical value for serum AHSG was 443.26 mg/L,with a sensitivity of 78.05%,specificity of 81.01%,and AUC of 0.771.For SF,the critical value was 192.32 ng/mL,with a sensitivity of 73.17%,specificity of 74.68%,and AUC of 0.875.The sensitivity,specificity and AUC of the combined diagnosis were 95.12%,94.94%and 0.929 at the optimal critical value.Conclusion The abnormal expressions of serum AHSG and SF are present in coronary heart disease patients with coronary slow flow,which are influencing factors for coronary slow flow and can be used to predict its occurrence.关键词
冠心病/冠状动脉慢血流/胎球蛋白A/铁蛋白Key words
Coronary heart disease/Coronary slow flow/Alpha-2-heremans-schmid glycoprotein/Serum ferritin引用本文复制引用
王丽霞,王运昌,李巧芬,张广强,张文菊..胎球蛋白A和铁蛋白表达与冠状动脉慢血流的相关性[J].心脑血管病防治,2025,25(2):27-31,5.基金项目
河北省邢台市重点研发计划项目(2022ZC247) （2022ZC247）
