中国病理生理杂志2025，Vol.41Issue(3)：600-605,6.DOI:10.3969/j.issn.1000-4718.2025.03.022
线粒体自噬与NLRP3炎症小体的相互作用在糖尿病视网膜病变中作用的研究进展
Progress in role of interaction between mitophagy and NLRP3 inflamma-some in diabetic retinopathy injury
摘要
Abstract
Diabetic retinopathy(DR)is one of the common serious microvascular complications in diabetic patients,with the main pathological features of retinal vascular injury,oxidative stress and chronic inflammatory re-sponse.In recent years,more and more studies have shown that mitophagy plays an important role in maintaining the func-tional homeostasis of retinal cells and preventing oxidative damage,and nucleotide-binding oligomerization domain-like re-ceptor protein 3(NLRP3)is a key regulator of pro-inflammatory response in DR.Mitophagy can reduce the excessive pro-duction of reactive oxygen species(ROS)by removing damaged mitochondria,thereby inhibiting the activation of NLRP3 inflammasome.In contrast,mitochondrial dysfunction can lead to excessive activation of NLRP3 inflammasome,which further aggravates the inflammatory response and apoptosis of the retina.Therefore,this article reviews the independent role of mitophagy and NLRP3 inflammasome in DR and their mutual regulatory mechanisms,so as to provide reference for the study of mitophagy and NLRP3 inflammasome as targets.关键词
糖尿病视网膜病变/线粒体自噬/NLRP3炎症小体Key words
diabetic retinopathy/mitophagy/NLRP3 inflammasome分类
医药卫生引用本文复制引用
王亦山,罗向霞,苏莉,柳青..线粒体自噬与NLRP3炎症小体的相互作用在糖尿病视网膜病变中作用的研究进展[J].中国病理生理杂志,2025,41(3):600-605,6.基金项目
国家自然科学基金资助项目(No.82360955) （No.82360955）
