中国感染控制杂志2025，Vol.24Issue(3)：430-436,7.DOI:10.12138/j.issn.1671-9638.20256688
泛连接蛋白1在感染中的研究进展
Research progress of pannexin 1 in infection
摘要
Abstract
Pannexin 1(PANX1)interacts with purinergic receptors through regulating immune responses,relea-sing adenosine triphosphate(ATP),and the NLRP3/caspase-1/interleukin(IL)-1β signaling pathway,then influ-ences the activation of immune cells and promotes the production of reactive oxygen species(ROS),thus causing in-flammation and tissue damage which exacerbates infection.This research group has synthesized new polypeptides named QE20 and EE20,which can specifically inhibit the opening of PANX1 channels under inflammatory stimula-tion,offering advantages such as reducing cellular ATP release,inhibiting inflammatory factor secretion,and pre-venting hepatocyte pyroptosis,et al.This review summarizes the roles and mechanisms of PANX1 in various infec-tious diseases,and predicts the feasibility of PANX1 as a potential therapeutic target in the future.关键词
泛连接蛋白1/感染/ATP/嘌呤能受体/合成肽/PANX1Key words
pannexin 1/infection/ATP/purinergic receptor/synthetic peptide/PANX1分类
医药卫生引用本文复制引用
徐志伟,王普森,张树斌,钟林..泛连接蛋白1在感染中的研究进展[J].中国感染控制杂志,2025,24(3):430-436,7.基金项目
国家科技部重点研发计划项目(2022YFC2304700) （2022YFC2304700）
国家自然科学基金委员会青年项目(82302427) （82302427）
深圳市高水平医院建设专项经费资助项目深圳市第三人民医院院级项目(XKJS-PWK-001) （XKJS-PWK-001）
上海市科学技术委员会实验动物研究领域项目(23141902000) （23141902000）
上海交通大学医工交叉基金青年项目(YG2023QNA26) （YG2023QNA26）
