中国临床药学杂志2025，Vol.34Issue(2)：87-92,6.DOI:10.19577/j.1007-4406.2025.02.002
基于"Chou-Talalay"模型分析794例缺血性脑梗死合并周围神经损伤病例的药对配伍作用
Exploration of the drug pairs interaction in 794 cases of ischemic cerebral infarction combined with peripheral nerve injury based on the"Chou-Talalay"model
摘要
Abstract
AIM Based on the"Chou-Talalay"model,the study analyzes the compatibility strength of drug pairs in patients with ischemic cerebral infarction combined with peripheral nerve injury(PNI),providing a rational methodology and evidence-based foundation for comprehensive clinical evaluation of drug efficacy and safety.METHODS The medication information of all patients with ischemic cerebral infarction combined with PNI in the Neurobrain Center from 2022 to 2023 was collected.The top 5 combined medication varieties and specifications for ischemic cerebral infarction and PNI were paired for analysis.Based on the"Chou-Talalay"model and CompuSyn 1.0 software,the CI value of the drug pair compatibility was calculated.Synergistic/antagonistic effects were determined according to CI thresholds:CI＜1.00(synergy),CI=1.00(additive)and CI＞1.00(antagonism),enabling quantitative assessment of compatibility effects.RESULTS Among patients with ischemic cerebral infarction combined with PNI,the main medications used for ischemic cerebral infarction were betahistine hydrochloride injection(81.23％),pentoxifylline injection(57.43％),edaravone dexbobornol concentrated solution injection(43.83％),butylphthalide sodium chloride injection(43.32％)and betahistine mesylate tablets(21.41％).PNI regulations were papaverine hydrochloride injection(11.96％),pregabalin capsules(10.45％),methylcobalamin capsules(8.56％),vitamin B6 tablets(5.54％)and eperisone hydrochloride tablets(4.41％).Under an 85％drug pair efficacy threshold,betahistine mesylate tablets had the greatest synergistic effect with each medicine for PNI,followed by pentoxifylline injection and butylphthalide sodium chloride injection(P=0.0193).Betahistine mesylate tablets and methylcobalamin tablets exhibited the strongest synergistic effect(CI=0.01),followed by butylphthalide sodium chloride injection and methylcobalamin tablets(CI=0.07).Notably,potential antagonistic interactions(CI＞1.00)were identified in the following combinations:betahistine hydrochloride injection combined with papaverine hydrochloride injection,and pentoxifylline injection coadministered with methylcobalamin tablets,vitamin B6 tablets,or eperisone hydrochloride tablets.CONCLUSION The application of the"Chou-Talalay"model to calculate the CI values of compatible drug pairs and quantify the intensity of drug interactions enables medical institutions to evaluate the efficacy and safety of combination therapies promptly.This approach establishes a feasible and robust baseline reference for enhanced continuous monitoring of clinical medication practices.关键词
"Chou-Talalay"模型/配伍/药物相互作用/缺血性脑梗死/周围神经损伤Key words
"Chou-Talalay"model/compatibility/drug interaction/ischemic cerebral infarction/peripheral nerve injury分类
药学引用本文复制引用
李亚昙,热义赛木·木尼热丁,蔡静,王亚勇,邱桂林..基于"Chou-Talalay"模型分析794例缺血性脑梗死合并周围神经损伤病例的药对配伍作用[J].中国临床药学杂志,2025,34(2):87-92,6.基金项目
新疆维吾尔自治区药学会科研基金项目(编号YXH202209) （编号YXH202209）
自治区天山创新团队项目(编号2023D14006) （编号2023D14006）
