中国输血杂志2025，Vol.38Issue(3)：397-401,425,6.DOI:10.13303/j.cjbt.issn.1004-549x.2025.03.014
苏州地区汉族人群MNS血型系统基因频率及多态性研究
Gene frequencies and polymorphism of the MNS blood group system in the Han population of voluntary blood do-nors in Suzhou
摘要
Abstract
Objective To investigate the antigen and gene frequency distribution of the MNS blood group system in the Han population of voluntary blood donors in Suzhou,and to explore the polymorphism of rare MNS blood group genes,in or-der to improve the construction of the local rare blood group database.Methods A total of 8 034 whole blood samples were randomly collected from Han blood donors at our station from October 2023 to June 2024.The MNS blood group phenotypes were identified using serological methods.Gene frequencies were analyzed and compared with those of ethnic populations in other regions.Rare MNS phenotype samples were subjected to gene sequencing.Results The distribution of MNS blood group system phenotypes within the population was as follows:the MM,NN,and MN phenotypes accounted for 23.00%,27.12%,and 49.88%respectively;the SS,ss,and Ss phenotypes accounted for 0.30%,90.99%,and 8.70%respec-tively.The gene frequencies of M,N,S,and s were 0.4794,0.5206,0.0465,and 0.9534 respectively.Chi-squared tests confirmed adherence to Hardy-Weinberg equilibrium with P-values of 0.997 and 0.349,showing statistical significance compared to some other regional ethnic populations(P<0.05).Additionally,one rare serological phenotype,S-s-,with a frequency of 0.01%,was identified.Conclusion The MNS blood group system in the Han population of voluntary blood donors in Suzhou exhibits polymorphism and regional distribution characteristics.Gene frequencies differ from those ob-served in other regions of China.It is essential to enhance the establishment of a rare blood type database in Suzhou to pro-vide data support for precise clinical transfusion.关键词
MNS血型系统/稀有血型/基因频率/基因多态性Key words
MNS blood group system/rare blood group/gene frequency/gene polymorphism分类
临床医学引用本文复制引用
徐子豪,傅晓燕,刘贞,蒋佳,金一鸣..苏州地区汉族人群MNS血型系统基因频率及多态性研究[J].中国输血杂志,2025,38(3):397-401,425,6.基金项目
苏州市卫生科技项目(GWZX202203) （GWZX202203）
姑苏卫生人才科研项目(GSWS2023032) （GSWS2023032）
苏州市医学重点学科(SZXK202118) （SZXK202118）
苏州市科技计划项目(SKYD2022042) （SKYD2022042）
江苏省输血协会爱康生物科研基金项(JSAK2022005) （JSAK2022005）
