摘要
Abstract
Objective To explore the current status,influencing factors,and serological characteristics of occult hepa-titis B virus infection(OBI)among blood donors in Xuzhou,so as to provide data support for improving blood safety screen-ing strategies.Methods Blood samples from blood donors from January 2019 to December 2023 in Xuzhou were tested u-sing enzyme-linked immunosorbent assay(ELISA)for serological markers and transaminase levels.Qualified samples were then subjected to nucleic acid testing(NAT).Statistical analysis was performed on the gender,age,education level,and occupation of HBV-infected donors.Logistic regression analysis was used to identify risk factors and epidemiological trends in OBI donors.Chemiluminescence immunoassay was used to quantify the levels of anti-HBs,HBeAg,anti-HBe,and anti-HBc in OBI donors and eligible donors(control group).Results Among the 545 292 blood donors,there were 388 OBI donors were identified,with a positive rate of 0.07%.Multivariate logistic regression analysis revealed that male gender,age>45 years,education below college level,and occupation as a farmer were associated risk factors for OBI infection.A-mong the 388 OBI donors,the predominant serological patterns were anti-HBs and anti-HBc positive(48.71%),anti-HBs,anti-HBe,and anti-HBc positive(16.75%),and anti-HBc alone positive(16.49%).In contrast,the most common pat-terns among eligible donors were anti-HBs alone positive(46.96%)and serologically negative(26.52%).Anti-HBs levels in OBI donors were significantly lower than those in eligible donors across all patterns(P<0.05).For donors positive for anti-HBc,the distribution of anti-HBs levels in OBI donors was predominantly<100 IU/L,significantly lower than that in eligible donors(P<0.05),while and the proportion of eligible donors with anti-HBs levels>1 000 IU/L was higher than that in OBI donors(P<0.05).Conclusion There is a certain proportion of OBI infections among blood donors in Xuzhou,with an overall declining trend.NAT contributes to improved detection rates of HBV infections.The epidemiological distri-bution of OBI donors in terms of gender,age,education,and occupation differs from that of eligible donors,and there are also differences in serological characteristics between the two groups.关键词
隐匿性乙型肝炎病毒感染/核酸检测/乙型肝炎血清学标志物/流行病学/献血者Key words
occult hepatitis B infection(OBI)/nucleic acid testing(NAT)/HBV serological markers/epidemiology/blood donors分类
临床医学
