中国输血杂志2025，Vol.38Issue(3)：448-454,7.DOI:10.13303/j.cjbt.issn.1004-549x.2025.03.022
免疫性血小板输注无效预防策略研究进展
Research progress on prevention strategies for immune platelet transfusion refractoriness
摘要
Abstract
Platelet transfusion refractoriness(PTR)is a common issue among patients with hematological diseases and tumors.This article reviews the diagnostic criteria,influencing factors,and recent prevention and management strategies for immune PTR.The diagnostic criteria typically involve post-transfusion platelet increment(PI),platelet recovery rate(PPR),and corrected count increment(CCI).Both immune and non-immune factors can lead to PTR,with immune fac-tors mainly including HLA and HPA antibodies.Prevention and management strategies include the use of leukocyte-reduced platelets,HLA and HPA antigen-matched platelets,intravenous immunoglobulin therapy,and immunosuppressive strate-gies.Although various strategies have been proposed and applied in clinical practice,the prevention and management of im-mune PTR remain challenging.Future research needs to explore more effective individualized treatment strategies,while al-so considering the potential application of emerging technologies such as nanotechnology in the field of transfusion.关键词
血小板输注无效/免疫性因素/诊断标准/预防策略Key words
platelet transfusion refractoriness/immune factors/diagnostic criteria/prevention strategies分类
医药卫生引用本文复制引用
赵沛喆,徐熠,梁雅珺,李卿,周源,许先国..免疫性血小板输注无效预防策略研究进展[J].中国输血杂志,2025,38(3):448-454,7.基金项目
中国输血协会威高科研基金重点项目(CSBT-MWG-202301) （CSBT-MWG-202301）
太原市科技局项目(ZC2024004) （ZC2024004）
太原市医学重点学科(基础输血学) （基础输血学）
太原市医学科技创新平台(血液安全及资源利用科技创新平台) （血液安全及资源利用科技创新平台）
