中国实验动物学报2025，Vol.33Issue(2)：249-258,10.DOI:10.3969/j.issn.1005-4847.2025.02.010
抑郁症动物模型的建立及评价方法研究进展
Development of an animal model of depression and evaluation methods
摘要
Abstract
Depression is a common chronic mental illness.Animal models of depression are widely used to study the pathogenesis of depression as well as in the development of new antidepressant drugs.The consistency and reliability of animal models of depression to simulate human depressive symptoms directly affect the study result.However,at present,no animal models have been found that are completely consistent with the onset of human depression,which hinders the in-depth study of depression.By using scientific and reasonable modeling and evaluation method,the pathological state of depression can still be simulated to a large extent,providing a basis for further in-depth research of the pathogenesis of depression and the development of effective antidepressant drugs.This paper aims to provide a reference for researchers by reviewing several commonly used animal models and behavioral tests of depression.关键词
抑郁症/动物模型/发病机制Key words
depression/animal model/molecular mechanism分类
生物学引用本文复制引用
刘子轩,霍清,孙雅煊,戴雪伶,李昕..抑郁症动物模型的建立及评价方法研究进展[J].中国实验动物学报,2025,33(2):249-258,10.基金项目
国家自然科学基金(11975048),北京联合大学校级科研项目(ZK10202204),北京联合大学校级教改项目(JY2023Y008). Funded by National Natural Science Foundation of China(11975048),the Academic Research Projects of Beijing Union University(ZK10202204),Education Reform Project of Beijing Union University(JY2023Y008). （11975048）
