中国实验动物学报2025，Vol.33Issue(2)：296-310,15.DOI:10.3969/j.issn.1005-4847.2025.02.015
阿尔茨海默病病证结合动物模型的研究进展
Research progress of Alzheimer's disease syndromes combined with animal models
摘要
Abstract
Alzheimer's disease(AD)is a common neurodegenerative disease.Traditional Chinese medicine is effective in treating AD.The combination of disease and syndrome with animal model is the basis and premise of related research.In this paper,studies on non-transgenic AD animal models and AD disease and syndrome combined animal models are summarized.It was found that,there are eight common non-transgenic AD animal models,including aging type(natural aging type,rapid aging type and induced aging type)and injection-induced injury type(Aβ injection animal model,Tau damage type,damage model of cholinergic system,neuroinflammatory model and aluminum poisoning induction model).AD disease and syndrome combined with animal models include kidney deficiency/kidney deficiency and essence deficiency/kidney deficiency and pulp emptying,phlegm turbidity blocking orifice,blood stasis blocking collaterals,phlegm stasis interlocking,liver depression and phlegm fluid stagnation heat.In this paper,the advantages and disadvantages of each model replication method are reviewed,in order to provide reference and support for the future study of AD disease and syndrome combined with animal models.关键词
阿尔茨海默病/动物模型/病证结合/研究进展Key words
Alzheimer's disease/animal model/combination of disease and syndrome/research progress分类
生物科学引用本文复制引用
李丽,严兴科,魏玉婷,窦婷婷..阿尔茨海默病病证结合动物模型的研究进展[J].中国实验动物学报,2025,33(2):296-310,15.基金项目
甘肃省中医药研究中心2024 年度专项开放课题(zyzx-2024-zx03),2023 年甘肃省省级重点人才项目(甘组通字[2023]20 号),2024 年高校教师创新基金项目(2024A-082). Funded by Gansu Research Center of Traditional Chinese Medicine 2024 Special Open Project(zyzx-2024-zx03),2023 Provincial Key Talent Project of Gansu Province(Gan Zu Tong Zi[2023]No.20),2024 College Teacher Innovation Fund Project(2024A-082). （zyzx-2024-zx03）
