中国实用妇科与产科杂志2025，Vol.41Issue(3)：348-352,5.DOI:10.19538/j.fk2025030118
子宫颈冷刀锥切术及筋膜外子宫切除术治疗ⅠA1期不伴淋巴脉管间隙浸润年轻子宫颈癌患者临床特征及预后对比分析
A comparison in the clinical characteristics and prognosis between cold knife conization of the cervix and extrafascial hysterectomy in the treatment of young patients with stage ⅠA1 cervical cancer without LVSI
摘要
Abstract
Objective To compare and analyze the clinical characteristics and prognosis of young patients with stageⅠA1 cervical cancer without lymphovascular space invasion by cold knife conization(CKC)and by extrafascial hysterectomy(EH).Methods This study retrospectively analyzed the clinical data of 153 patients(≤45 yeas old)with stage ⅠA1 cervical cancer who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2013 to September 2023.According to different surgical methods,they were divided into CKC group(53 cases)and EH group(100 cases).The clinical characteristics,perioperative indexes and prognosis of the two groups were compared and analyzed,and the fertility outcomes of the patients in the CKC group were followed up.Results Compared with the CKC group,the EH group had significantly longer operation time[(89.0±33.3)min vs.(47.6±26.1)min],first postoperative flatus time[(2.2±0.5)d vs.(1.3±0.5)d],indwelling catheter time[(2.0±0.6)d vs.(1.2±0.4)d]and postoperative hospital stay[(5.3±1.7)d vs.(3.8±1.7)d],and significantly more intraoperative blood loss[(33.2±27.2)mL vs.(13.1±14.6)mL](P＜0.001).In the EH group,6 patients(6.0％)had postoperative complications.The 3-year DFS and OS of both groups were 100.0％(P＞0.05).In the CKC group,the postoperative pregnancy rate was 63.2％(12/19),the live birth rate was 46.2％(6/13),and the premature birth rate was 50.0％(3/6).Conclusions CKC is a surgical procedure with small damage.Patients treated with CKC have a fast postoperative recovery and good prognosis and fertility outcomes,and CKC can be used as a clinical choice for young patients(≤45 years old)with stage ⅠA1 cervical cancer without LVSI.关键词
ⅠA1期子宫颈癌/子宫颈冷刀锥切术/筋膜外子宫切除术/年轻患者/预后Key words
stage ⅠA1 cervical cancer/cold knife conization of the cervix/extrafascial hysterectomy/young patients/prognosis分类
医药卫生引用本文复制引用
杜欣颖,刘亚娜,严淑萍,付翰林,毛萌,王倩,郭瑞霞..子宫颈冷刀锥切术及筋膜外子宫切除术治疗ⅠA1期不伴淋巴脉管间隙浸润年轻子宫颈癌患者临床特征及预后对比分析[J].中国实用妇科与产科杂志,2025,41(3):348-352,5.基金项目
河南省中青年卫生健康科技创新领军人才培养项目(YXKC2020012) （YXKC2020012）
