中国药物评价2025，Vol.42Issue(1)：49-53,5.
清肺抑火片中6种植物生长调节剂的检测研究
Study on the Detection of 6 Plant Growth Regulators in Qingfei Yihuo Tablet
摘要
Abstract
Objective:To establish a method for the detection of6 plant growth regulators in Qingfei Yihuo tablet,and to evaluate the quality of Qingfei Yihuo tablet from the aspect of safety.Methods:Ultra high performance liquid chromatography-triple quadrupole tan-dem mass spectrometry was used to detect six plant growth regulators in Qingfeiyihuo tablet,including butyrin,acetamide,buty-rhydrazine,pyridinol,polybutyrazole and tenbutyrazole.Results:Among the 34 batches of Qingfei Yihuo tablet samples,the content of nebulocin in 10 batches of samples produced by 3 manufacturers ranged from 7.3 μg·kg-1 to 238.9 µg·kg-1,and the other compo-nents were not detected.The linear relationship of each component was good(r=0.991 2-0.999 9),and the recoveries of each compo-nent were 60％-80％,RSD was 6.4％-11.2％.Conclusion:The UPLC/MS method for the simultaneous detection of six plant growth regulators in Qingfeiyihuo tablets,including butanylhydrazine,pyridinol,polybutenazole and tenbutenazole,has high accuracy,strong specificity and practicability,and can provide technical support for drug regulation.关键词
清肺抑火片/植物生长调节剂/超高液相色谱串联质谱/检测Key words
Qingfei yihuo tablet/Plant growth regulator/Ultra high performance liquid chromatography-tandem mass spectrometry/Detection分类
中医学引用本文复制引用
范秀春,罗廷顺,徐维二,缪明锦,董坤..清肺抑火片中6种植物生长调节剂的检测研究[J].中国药物评价,2025,42(1):49-53,5.基金项目
2022年云南省药品评价抽检计划项目(云药监办2022-07) （云药监办2022-07）
