摘要
Abstract
Objective:To analyze the efficacy and safety of Yunkang Granules combined with progesterone in the treatment of patients with recurrent abortion.Methods:Retrospectively selected 106 patients with recurrent miscarriage received by Nanyang Downtown Hospi-tal from December 2021 to April 2023 as the study object,and divided into conventional group and combined group based on different treatment programs,each with 53 cases.The conventional group received progesterone treatment,while the combined group received pro-gesterone+Yunkang Granules.The clinical efficacy,safety,and pregnancy outcomes of the two groups were compared,as well as the TCM syndrome scores(vaginal bleeding,waist pain,abdominal pain,dizziness,tinnitus,and cold limbs),estradiol(E2),progesterone,human chorionic gonadotropin(β-HCG),D-dimer(D-D),activated partial thromboplastin time(APTT),plasminogen activator inhibitor-1(PAI-1),tissue-type plasminogen activator(t-PA),and prothrombin time(PT)levels before and after treatment.Results:The clinical efficacy of the combined group was 94.34％,which was higher than that of the conventional group's 81.13％(P＜0.05).After treat-ment,the scores of waist pain,abdominal pain,vaginal bleeding,cold limbs,dizziness and tinnitus in the combined group were lower than those in the conventional group(P＜0.05).After treatment,the levels of β-HCG,E2,and progesterone in the combined group were higher than those in the conventional group(P＜0.05).After treatment,the levels of PAI-1,D-D,and t-PA in the combined group were lower than those in the conventional group,while the levels of APTT and PT were higher than those in the conventional group(P＜0.05).The incidence of adverse reactions in the combined group was 5.66％(3/53),which was not significantly different from the conventional group's 9.43％(5/53)(P＞0.05).After a 9 months follow-up,the pregnancy success rate in the combined group was 89.80％,which was higher than the 74.47％in the conventional group(P＜0.05).Conclusion:The combination of Yunkang Granules and progesterone is safe and effective for treating recurrent miscarriage.It can regulate sex hormone levels,improve clinical symptoms and coagulation func-tion,and enhance pregnancy success rates.关键词
孕康颗粒/黄体酮/复发性流产/安全性Key words
Yunkang Granules/Progesterone/Recurrent abortion/Safety分类
医药卫生
