中国医学装备2025，Vol.22Issue(3)：22-28,7.DOI:10.3969/j.issn.1672-8270.2025.03.005
基于两种旋转照射模式下宫颈癌患者行骨盆保护的剂量学研究
Dosimetric study of undergoing pelvic protection for patients with cervical cancer based on two kinds of rotational irradiation modes
摘要
Abstract
Objective:To compare the dosimetric differences between volumetric modulated arc therapy(VMAT)and helical tomotherapy(HT)in undergoing protective plan for pelvic bones of patients with cervical cancer.Methods:A total of 40 patients with cervical cancer,who underwent radiotherapy at the First Affiliated Hospital of Bengbu Medical University from January 2023 to February 2024,were selected for this study.The target volumes and organs at risk(OARs)were delineated after the information of computed tomography(CT)simulation images were acquired from each patient.The pelvic bone was alone delineated as OAR.Two kinds of bone marrow dose-limiting radiotherapy plans,coplanar dual-arc VMAT and HT,were respectively designed for each patient by using the treatment planning system(TPS)of radiotherapy.A statistical analysis was conducted to compare the dose parameters of target volume,conformity,homogeneity,OAR dose-volume,mean dose,and maximum dose of point between the two kinds of plans.Results:Both the VMAT and HT plans could meet the requirements of target volume and OARs for dose.For general OARs,the dose-volume percentage(V40 Gy)of V40 Gy at bladder,mean dose(Dmean),rectal V40 Gy,maximum dose(Dmax)at small intestine point of HT plan were respectively(38.97±2.29)%,(38.06±0.45)Gy,(61.50±2.51)%and(50.82±0.36)Gy.The differences of them between HT plan and VMAT plan were statistically significant(t=25.46,13.99,1.56,10.93,P<0.05).The V10 Gy,V20 Gy,V30 Gy and Dmean of VMAT plan were respectively(70.76±2.51)%,(60.84±3.29)%,(52.40±2.56)%and(32.02±4.33)Gy for pelvic bones,which were significantly lower than those of HT plan,and the differences of them between two kinds of plans were also statistically significant(t=-20.68,-13.23,-7.73,-10.26,P<0.05).Conclusion:The HT plan can provide the optimal dose distribution for target region in radiotherapy for patients with cervical cancer,which can better protect OAR nearby target region.VMAT plan has a significant advantage in low-dose regions of protecting pelvis.Thus,individualized treatment design should be conducted according to the conditions of each patient in clinical treatment.关键词
宫颈癌/容积旋转调强放射治疗(VMAT)/旋转照射模式/剂量学/骨髓抑制Key words
Cervical cancer/Intensity modulated radiotherapy(IMRT)/Rotational irradiation modes/Dosimetry/Bone marrow depression分类
医药卫生引用本文复制引用
仇好,张菲菲,毕春,唐天红,李文静,石善成,王佳佳,施前进..基于两种旋转照射模式下宫颈癌患者行骨盆保护的剂量学研究[J].中国医学装备,2025,22(3):22-28,7.基金项目
泗阳医院与江苏大学附属医院第一届院内科技计划(2024SY007) The First Internal Science and Technology Program of Siyang Hospital and the Affiliated Hospital of Jiangsu University(2024SY007) （2024SY007）
