Abstract
Objective To investigate the correlation between serum IL-6,cystatin C(CysC),triiodothyronine(T3)levels,and total imaging burden score with cognitive impairment in patients with cerebral small vessel disease(CSVD).
Methods CSVD patients treated from January 2021 to January 2023 were retrospectively included and subsequently divided into the cognitive impairment group and the normal cognitive function group based on their MoCA scores during hospitalization.The demographic information,past medical history,and laboratory and imaging data of the patients were collected.The predictive value of serum IL-6,CysC,T3,and total imaging burden score for cognitive impairment in CSVD patients was analyzed.
Results A total of 142 patients with CSVD were included,with 61 cases(43.0%)in the cognitive impairment group and 81 cases(57.0%)in the normal cognitive function group.The levels of IL-6,Hcy,and CysC were higher,the level of T3 was lower,and the proportion of moderate to severe total imaging burden was higher in the cognitive impairment group,with statistically significant differences.Multivariate logistic regression analysis showed that elevated serum IL-6 levels(OR1.070,95%CI1.039-1.103,P＜0.001),elevated CysC levels(OR2.117,95%CI1.027-5.500,P=0.004),decreased T3 levels(OR2.314,95%CI1.361-3.935,P=0.003),and moderate(OR1.017,95%CI 1.002-1.032,P=0.029)and severe(OR9.032,95%CI6.076-18.012,P＜0.001)total imaging burden were risk factors for cognitive impairment in patients with CSVD.The AUC values for predicting cognitive impairment of serum IL-6,CysC,T3,and severe total imaging burden were 0.888,0.812,0.918,and 0.889,respectively,with the optimal cutoffvalues of 2.010 pg/mL,0.982 ng/L,1.302 nmol/L,and 3.6 points.
Conclusions Elevated serum IL-6 and CysC levels,decreased T3 levels,and severe total imaging burden are correlated with cognitive impairment in patients with CSVD and can serve as a basis for identifying cognitive impairment in CSVD patients.关键词
脑小血管病/认知障碍/白细胞介素6/甲状腺激素/影像学总负荷Key words
Cerebral small vessel disease/Cognitive impairment/Interleukin-6/Thyroid hormone/Total imaging burden分类
临床医学
