中国卒中杂志2025，Vol.20Issue(3)：373-379,7.DOI:10.3969/j.issn.1673-5765.2025.03.016
脑出血患者卒中前痴呆与院内结局:基于中国卒中中心联盟登记数据库的分析
Pre-Stroke Dementia and In-Hospital Outcomes in Patients with Intracerebral Hemorrhage:An Analysis Based on the China Stroke Center Alliance Registry Database
摘要
Abstract
Objective To investigate the prevalence of pre-stroke dementia in patients with intracerebral hemorrhage and its relationship with in-hospital outcomes. Methods The data for this study were derived from patients with intracerebral hemorrhage enrolled in the China Stroke Center Alliance registry database from August 2015 to December 2022.The determination of pre-stroke dementia was based on self-reports in the patient's medical history.In-hospital outcomes included walking within 2 days of admission,stroke recurrence,in-hospital death,in-hospital complications(pulmonary embolism,pneumonia,etc.),and discharge to home.Multivariate logistic regression was used to analyze the correlation between pre-stroke dementia and in-hospital outcomes in patients with intracerebral hemorrhage. Results A total of 109 366 patients with intracerebral hemorrhage were enrolled in this study,including 68 386(62.5%)males,aged 63.0(53.0-72.0)years.The NIHSS score at admission was 6.0(2.0-13.0)points,and the length of hospitalization was 15.0(10.0-21.0)days.A total of 293(0.3%)patients had a history of pre-stroke dementia.Compared with patients without pre-stroke dementia,patients with pre-stroke dementia were older,had a higher proportion of females,and had lower levels of education.Multivariate logistic regression analysis showed that pre-stroke dementia may be associated with a higher risk of in-hospital complications(OR2.35,95%CI1.46-3.83),particularly pneumonia(OR2.52,95%CI1.57-4.08).However,there were no significant differences in outcomes such as stroke recurrence(OR1.45,95%CI0.63-2.88),in-hospital death(OR1.43,95%CI0.80-2.50),and discharge to home(OR0.83,95%CI0.46-1.60)between the two groups. Conclusions In this study,the prevalence of pre-stroke dementia in patients with intracerebral hemorrhage was 0.3%,and pre-stroke dementia may increase the risk of in-hospital complications,particularly pneumonia,in patients with intracerebral hemorrhage.关键词
脑出血/卒中前痴呆/患病率/院内结局Key words
Intracerebral hemorrhage/Pre-stroke dementia/Prevalence/In-hospital outcome分类
医药卫生引用本文复制引用
李秋菊,尹金风,王春娟,杨昕,任添华,李子孝,谷鸿秋,姜勇..脑出血患者卒中前痴呆与院内结局:基于中国卒中中心联盟登记数据库的分析[J].中国卒中杂志,2025,20(3):373-379,7.基金项目
科技创新2030项目(2021ZD0200801) （2021ZD0200801）
