中华耳科学杂志2025，Vol.23Issue(2)：228-233,6.DOI:10.3969/j.issn.1672-2922.2025.02.010
短期多元整合声对慢性主观性耳鸣患者的疗效及对大脑皮层神经活动的影响
Effects of Short-Term Multi-Component Integrated Sounds on Patients with Chronic Subjective Tinnitus and on Cerebral Cortical Neural Activities
摘要
Abstract
Objective To evaluate the efficacy of short-term multiple integrated sounds(MIS)in the treatment of chronic subjective tinnitus,and their effects on cerebral cortical neural activities in patients with chronic subjective tinnitus based on oxygenated hemoglo-bin(HbO),as well as their correlation.Methods Patients with chronic subjective tinnitus(n=180)were prospectively selected from the Otolaryngology Department,Affiliated Hospital of North Sichuan Medical College from January 2023 to March 2023,and randomly divided into a MIS treatment group and a control group to be treated with traditional narrowband noise(90 in each).Treatment session was 15 min.Tinnitus Handicap Inventory(THI)scores and visual analogue scale(VAS)scores were used to evaluate tinnitus severity before and after treatment.Functional near-infrared spectroscopy(FNIRS)was used to determine hemoglobin oxygenation at frontal polar cortex(FPC-HbO),dorsolateral prefrontal cortex(DPFC-HbO),temporal cerebral cortex(TL-HbO),occipital cerebral cortex(OL-HbO)and parietal cerebral cortex(PL-HbO).Results Before treatment,there was no significant difference in THI and VAS scores between the two groups(P＞0.05).After treatment,the THI score showed no significant difference compared to before treatment or between the two groups(P＞0.05).The post-treatment VAS score decreased in both groups,more so in the MIS group(P＜0.05).Post-treatment DFC-HbO and TL-HbO increased in both groups(P＜0.05),but FPC-HbO decreased(P＜0.05),while PL-HbO and OL-HbO showed no significant change(P＞0.05).FPC-HbO change in the MIS group was greater than in control group(P＜0.05).The FPC hemodynamic topographic map showed no significant before and after treatment change in the control group,but reduced HbO concentration in the MIS group.The change of FPC-HbO in the MIS group was positively correlated with VAS score changes(r=0.540,P＜0.05).Conclusion Short-term MIS can change neuronal activities in the frontal cortex and reduce perceived tinnitus in patients with chronic subjective tinnitus,and the appear to be correlated.关键词
耳鸣/声治疗/多元整合声治疗/额极皮层/氧合血红蛋白/耳鸣致残量表Key words
tinnitus/sound therapy/multiple integrated sound therapy/frontal polar cortex/oxygenated hemoglobin/tinnitus handicap inventory引用本文复制引用
潘庆春,李蓓,冯燚源..短期多元整合声对慢性主观性耳鸣患者的疗效及对大脑皮层神经活动的影响[J].中华耳科学杂志,2025,23(2):228-233,6.基金项目
南充市社会科学研究"十四五"规划2024年度项目(NC24B211,NC24C150) （NC24B211,NC24C150）
川北医学院临床医学院·附属医院2024年度科研发展计划(2024GC014) （2024GC014）
川北医学院2023年度本科教学工程立项建设项目(JG20230111) （JG20230111）
川北医学院2024年本科教学工程项目(CXSY24-27,CXSY24-23,XNFZ24-23,XNFZ24-24,XNFZ24-29) （CXSY24-27,CXSY24-23,XNFZ24-23,XNFZ24-24,XNFZ24-29）
