中华耳科学杂志2025，Vol.23Issue(2)：256-260,5.DOI:10.3969/j.issn.1672-2922.2025.02.014
不同年龄小型猪听觉失匹配负波的波形特征分析
Characteristics of Auditory Mismatch Negativity in Miniature Pigs at Different Ages
摘要
Abstract
Objective To report characteristics of mismatch negativity(MMN)in miniature pigs of different ages and discuss their roles in research on central auditory development and function.Methods Auditory MMN tests were performed using the classic Oddball stimulus paradigm on a Smart EP auditory evoked potential system in 3 and 6-month-old normal-hearing male miniature pigs(6[12 ears]each)under anesthesia.The latency and amplitude were analyzed using the SPSS 25.0 software.Results Eleven of the 12 miniature pigs(22 ears,91.67%)exhibited typical auditory MMN waveforms.The average latency was 230.73±42.90 ms,266.10±20.22 ms in the 3-month-old group and 201.25±33.08 ms in the 6-month-old group(P＜0.01).The mean amplitude was 3.28±2.28 µV with no significant difference between the two age groups(P＞0.05).Conclusion Auditory MMN waveforms,latency and developmental trend in miniature pigs are similar to those in humans,suggesting that miniature pigs can serve as an appropriate animal model for studying central auditory development and function.关键词
失匹配负波/小型猪/听觉中枢/发育/潜伏期/振幅Key words
mismatch negativity/miniature pigs/central auditory/development/latency/amplitude引用本文复制引用
唐菲,杨崇灵,郭维维,吕萍,刘军..不同年龄小型猪听觉失匹配负波的波形特征分析[J].中华耳科学杂志,2025,23(2):256-260,5.基金项目
国家自然科学基金项目(82371148) （82371148）
