中华耳科学杂志2025，Vol.23Issue(2)：289-293,5.DOI:10.3969/j.issn.1672-2922.2025.02.020
与耳聋相关的机械-电转导通道相关基因研究进展
The Relationship between Mechanoelectrical Transduction Channel Genes and Deafness:A Review
摘要
Abstract
Mechanoelectrical transduction(MET)channels are one of the key links in the conversion of acoustic physical signals into electrical signals by inner ear hair cells.They are macromolecular protein complexes and essential for mammalian hearing and balance functions.The exact molecular composition of the MET channel complex is not clear.At present,the known MET channel-related proteins include TMC1/2,LHFPL5,TMIE and CIB2.Alteration or deletion of the these proteins can lead to abnormalities in MET channel structure and function,resulting in hearing loss.This article reviews the MET channel and related genes,and discusses the correlation between MET channel related gene mutations and deafness.关键词
机械-电转导通道/LHFPL5/TMC1/2/TMIE/耳聋Key words
the mechanoelectrical transduction channel(MET channel)/LHFPL5/TMC1/2/TMIE/deafness引用本文复制引用
梁明静,於镇寰,庞秀红..与耳聋相关的机械-电转导通道相关基因研究进展[J].中华耳科学杂志,2025,23(2):289-293,5.基金项目
江苏省卫生健康委科研课题(M2022067) （M2022067）
泰州市科技支撑(社会发展)项目(TS202214) （社会发展）
国家自然科学基金(81700920) （81700920）
江苏省基础研究计划项目(自然科学基金)面上项目(BK20191229) （自然科学基金）
江苏省第五期"333工程"科研项目(BRA2019192) （BRA2019192）
