中华耳科学杂志2025，Vol.23Issue(2)：294-300,7.DOI:10.3969/j.issn.1672-2922.2025.02.021
代谢组学技术分析对感音神经性聋的预防与治疗应用展望
Prospective Application of Metabolomics Analysis in Prevention and Treatment of Sensorineural Deafness
摘要
Abstract
Sensorineural hearing loss(SNHL)is a prevalent sensory disorder whose pathogenesis and effective therapeutic strategies remain poorly understood.Identifying its biomarkers is of significant importance.Metabolomics,a technology that enables the analysis of small-molecule metabolites in biological samples,provides a quantitative approach to studying metabolic alterations.This approach has the potential to elucidate the mechanisms underlying various forms of SNHL and to aid in differential diagnosis and treatment.In this review,we summarize recent advances in metabolomic research on SNHL,including the sources of samples,analytical techniques,identified metabolic changes,and their biological significance.Key metabolites such as arginine,methionine,alanine,glutamate,homocysteine,tryptophan,pantothenic acid,acylcarnitine,sphingosine,and N-acetylneuraminic acid were found to exhibit significant alterations.Notably,the levels of numerous oxidative stress-related metabolites were observed to change following injury.Pathway enrichment analysis of differential metabolites suggests that SNHL is closely associated with oxidative stress networks and neuroprotective mechanisms.Metabolomics,an emerging analytical technology,holds promise for identifying novel therapeutic targets and strategies for precise treatment of SNHL.关键词
感音神经性听力损失/代谢组学/氧化应激/精准治疗Key words
sensorineural hearing loss/metabonomics/oxidative stress/precise treatment引用本文复制引用
范晗琪,黎奥,徐继峰,李思雨,张圆,杨霞,刘丁丁,钱晓云,高下..代谢组学技术分析对感音神经性聋的预防与治疗应用展望[J].中华耳科学杂志,2025,23(2):294-300,7.基金项目
国家自然科学基金(82192862,82101223) （82192862,82101223）
江苏省重点医学学科/实验室项目(ZDXK202243) （ZDXK202243）
