中华耳科学杂志2025，Vol.23Issue(2)：305-309,5.DOI:10.3969/j.issn.1672-2922.2025.02.023
组学技术在中耳炎领域的应用
Application of Omics Technology in Management of Otitis Media
摘要
Abstract
Otitis media(OM)refers to an inflammatory lesion in the middle ear caused by bacterial or viral infections,which is a common disease in clinical otolaryngology,usually involving children with common symptoms including ear pain,hearing loss and ear discharge.At present,antibiotics and surgery are often used to treat OM in the clinic,but there are adverse reactions and complications after medication.Therefore,it is urgent to study the pathophysiological mechanism of OM in order to improve treatment methods.The rapid development of high-throughput technology enables omics techniques to comprehensively analyze a large number of similar biomolecules or single molecules simultaneously.Discovery of new biomarkers using omics technology deepens researchers'understanding of the pathological and physiological mechanisms of OM,providing new ideas for diagnosis,treatment and prevention.We will review the latest developments in the application of omics technologies in the management of OM from five aspects:genomics,proteomics,metabolomics,transcriptomics and microbiomics.关键词
中耳炎/基因组学/蛋白质组学/代谢组学/转录组学/微生物组学Key words
otitis media/genomics/proteomics/metabolomics/transcriptomics/microbiomics引用本文复制引用
张凯,吴远程,唐丽欢,胡娟,都梦贤,李博..组学技术在中耳炎领域的应用[J].中华耳科学杂志,2025,23(2):305-309,5.基金项目
国家自然科学基金(82371137 （）
82171143 （）
81530030) （）
山东省自然科学基金(ZR2024MH263) （ZR2024MH263）
山东省优质专业学位教学案例库项目(SDYAL2022186 （）
SDYKC2023184) （）
滨州医学院教学改革与研究项目(JYKTMP2021013) （JYKTMP2021013）
