中山大学学报（自然科学版）（中英文）2025，Vol.64Issue(2)：94-102,9.DOI:10.13471/j.cnki.acta.snus.ZR20240251
纳米酶修饰植入式微电极对电化学传感性能的提升作用与应用研究
Nanoenzymes modified implantable microelectrodes for enhanced electrochemical sensing performance
摘要
Abstract
We investigated the modification of three types of nanoenzymes(Au24Cd1,Au24Er1,and Au25)on Ag microelectrodes(AgME),Au microelectrodes(AuME),and electrocorticography microelectrode(EcoGME).In this study,three distinct nanoenzymes were successfully immobilized onto the surfaces of three different electrodes.The electrodes modified with nanoenzymes mitigated the inherently high impedance characteristic of conventional neuroelectrodes.Meanwhile,we investigated the effect of nanoenzymatic modifications on different electrochemical recording methods,including electrochemical impedance spectroscopy,cyclic voltammetry,differential pulse voltammetry,square wave pulse voltammetry,normal pulse voltammetry and linear scanning voltammetry.By investigating the effects of various nanoenzyme materials,electrode substrates,and detection methods in neural signal acquisition applications,the findings provide more precise and efficient sensing options for neuroscience research and clinical practice.关键词
纳米酶/植入式微电极/电化学检测Key words
nanoenzyme/implantable microelectrodes/electrochemical detection分类
化学引用本文复制引用
阳瀚祺,徐兴元,张晓东,陈惠琄,谢曦,黄爽,刘静,刘爽杰,刘铮杰,陈家宜,高路康,黄新烁,姚传捷..纳米酶修饰植入式微电极对电化学传感性能的提升作用与应用研究[J].中山大学学报（自然科学版）（中英文）,2025,64(2):94-102,9.基金项目
国家重点研发计划(2021YFF1200700) （2021YFF1200700）
国家自然科学基金(T2225010,32171399,32171456) （T2225010,32171399,32171456）
中国博士后科学基金(2023TQ0386) （2023TQ0386）
广东省基础与应用基础研究基金(2023A1515011267,2023A1515111139) （2023A1515011267,2023A1515111139）
