中华中医药学刊2025，Vol.43Issue(3)：47-55,9.DOI:10.13193/j.issn.1673-7717.2025.03.008
微生物群参与子宫内膜异位症发病机制的研究现况
Advances of Microbiome Involvement in Pathogenesis of Endometriosis
摘要
Abstract
As a common and frequently-occurring gynecological disease,endometriosis(EM)is an important cause of chro-nic pelvic pain and infertility in women,which seriously troubles many women of childbearing age.Because of its unknown etiolo-gy,extensive lesions,extremely invasive and easy to relapse characteristics,EM is also an intractable disease.More and more re-search evidence in recent years has shown that the intestinal microbiota,female reproductive tract microbiota and peritoneal micro-biota of EM patients are significantly different from those of healthy women,indicating that there is a close correlation between the etiology of EM and the disorder of the microbiome in vivo.It is suggested that the microbiota may affect the occurrence and pro-gression of EM through immune-inflammatory pathways and metabolic pathways(enhanced estrogen metabolism,abnormal lipid metabolism,etc.).To date,studies on EM-related microbiotm have found some possible specific strains,which are expected to be biomarkers for early non-invasive diagnosis of EM.At the same time,dietary intervention,supplementation with probiotics or prebiotics and microbial transplantation can help to prevent and alleviate EM symptoms and provide potential treatments.Studies showed that there was a potential relationship between the cold-heat nature of TCMs and its modulation effects on gut microbio-ta.The TCM and its compounds which can promote blood circulation and removing blood stasis have obvious effects on modula-ting gut microbiota structure and protecting intestinal barrier function.In this paper,it reviewed the current research progress of microbiota involvement in the pathogenesis of EM,and looked forward to the potential treatment of EM through microbial approach in the future.关键词
子宫内膜异位症/微生物群/发病机制Key words
endometriosis/microbiome/pathogenic mechanism分类
医药卫生引用本文复制引用
邱天,张婷婷,庄梦斐..微生物群参与子宫内膜异位症发病机制的研究现况[J].中华中医药学刊,2025,43(3):47-55,9.基金项目
国家自然科学基金面上项目(82374499,82074475) （82374499,82074475）
国家自然科学基金青年科学基金项目(82104906) （82104906）
海派中医流派传承创新团队建设项目(2021LPTD-002) （2021LPTD-002）
上海市进一步加快中医药传承创新发展三年行动计划项目(ZY[2021-2023]0302) （ZY[2021-2023]0302）
