巴楚医学2025，Vol.8Issue(1)：96-103,8.DOI:10.3969/j.issn.2096-6113.2025.01.017
循环肿瘤细胞与结直肠癌患者不良预后的Meta分析
Meta Analysis of Circulating Tumor Cells and Adverse Prognosis in Colorectal Cancer Patients
摘要
Abstract
Objective:To investigate the relationship between circulating tumor cells(CTC)and prognosis in colorectal cancer patients.Methods:Relevant literature on CTC and prognosis of colorectal cancer patients was retrieved from PubMed,Embase,Web of Science,Medline,CNKI,VIP,Wanfang databases,covering the period from January 1,2007 to January 1,2024.After data extraction,R language was used for data analysis.Results:A total of 14 articles involving 2,378 patients were included in this study.The results of the meta-analysis indicated that colorectal cancer patients with circulating tumor cells(CTC+)had significantly shorter overall survival(HR=1.93,95％CI:1.56,2.39)and progression-free survival(HR=1.91,95％CI:1.46,2.50)compared to those without circulating tumor cells(CTC-).In the subgroup with CTCs≥3/7.5 mL,CTC+patients had even shorter overall survival(HR=2.18,95％CI:1.62,2.93)and progression-free survival(HR=1.75,95％CI:1.21,2.53)than CTC-patients.Conclusion:CTC is an important indicator of poor prognosis in colorectal cancer patients.CTC detection can serve as an effective measure for assessing the prognosis of colorectal cancer patients,providing significant reference for early identification of high-risk patients and actively making treatment decisions.关键词
结直肠癌/循环肿瘤细胞/Meta分析/总生存期/无进展生存期Key words
colorectal cancer/circulating tumor cells(CTC)/meta-analysis/overall survival/progression-free survival分类
医药卫生引用本文复制引用
贺玲,徐兴东,赵海龙..循环肿瘤细胞与结直肠癌患者不良预后的Meta分析[J].巴楚医学,2025,8(1):96-103,8.基金项目
湖北省卫生健康委科研项目(WJ2021M067) （WJ2021M067）
湖北省知识创新专项项目(2018FB440) （2018FB440）
