巴楚医学2025，Vol.8Issue(1)：114-118,5.DOI:10.3969/j.issn.2096-6113.2025.01.020
PI3K/AKT/mTOR信号通路在食管鳞状细胞癌中的作用机制研究进展
Research Progress on the Mechanism of PI3K/AKT/mTOR Signaling Pathway in Esophageal Squamous Cell Carcinoma
摘要
Abstract
PI3K/Akt/mTOR signaling pathway is involved in the metastasis,invasion and angiogenesis of esophageal squamous cell carcinoma(ESCC)by regulating the growth,proliferation,survival and metabolism of esophageal cancer cells.This review summarizes the pathogenesis of ESCC,especially the relationship between PI3K/Akt/mTOR signaling pathway and the progression of ESCC,as well as the current research and development progress of new drugs targeting PI3K/Akt/mTOR signaling pathway,in order to provide some reference for the related research and the construction of new treatment strategies for ESCC.关键词
PI3K/Akt/mTOR信号通路/食管鳞状细胞癌/靶向治疗Key words
PI3K/Akt/mTOR signaling pathway/esophageal squamous cell carcinoma(ESCC)/targeted therapy分类
医药卫生引用本文复制引用
乐梓阳,胡毅,刘烨,王艳华..PI3K/AKT/mTOR信号通路在食管鳞状细胞癌中的作用机制研究进展[J].巴楚医学,2025,8(1):114-118,5.基金项目
国家自然科学基金青年项目(81602559) （81602559）
