重庆医学2025，Vol.54Issue(3)：588-592,5.DOI:10.3969/j.issn.1671-8348.2025.03.005
双重血浆分子吸附序贯血浆置换治疗肝衰竭的临床疗效分析
Analysis on clinical efficacy of dual plasma molecular adsorbent sequential plasma exchange in treatment of liver failure
摘要
Abstract
Objective To explore the clinical efficacy of dual plasma molecular adsorption(DPMAS)sequential plasma exchange(PE)artificial liver mode in the treatment of liver failure(LF).Methods Eighty-five patients with LF receiving the artificial liver treatment in the Affiliated Hospital of Zunyi Medical Univer-sity from January 2020 to December 2023 were selected as the study subjects and divided into the study group(n=52)and the control group(n=33)according to the different treatment modes.The study group conduc-ted DPMAS sequential PE treatment and the control group underwent the PE treatment.The liver function[total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum albumin(ALB),globulin(GLO),prealbumin(PAB)],Hb,coagulation function[platelet(PLT),plasminogen activity(PTA),international normalized ratio(INR),fibrinogen(FIB)]before treatment and at 24 h after treatment were compared between the two groups.Results Compared with before treatment,the levels of TBIL,ALT,AST,GLO and Hb after the first and second treatment in the two groups were decreased,ALB level in the control group and PAB level after the second time treatment was increased(P＜0.05).Compared with after the first treatment,the levels of TBIL,ALT and GLO after the second treatment in the two groups and the levels of AST and Hb in the study group were decreased,ALB level in the study group and PAB level in the two groups were increased(P＜0.05).Compared with before treatment,the levels of PLT and FIB after the first treatment in the two groups and INR level in the control group were decreased,PTA level in the control group was increased(P＜0.05).Compared with before treatment,the levels of PLT,INR and FIB after the second treatment in the two groups were decreased,PTA level was increased(P＜0.05).Compared with be-fore treatment,the levels of PLT,INR and FIB after the second treatment in the two groups were decreased,and PTA level was increased(P＜0.05).Compared with after the first treatment,PTA level after the second treatment in the study group was increased and INR level was decreased.Conclusion PE and DPMAS sequen-tial PE all could improve the liver function in the patients with LF,moreover the two times treatment has more significant effect.关键词
肝衰竭/双重血浆分子吸附/血浆置换/人工肝/凝血功能Key words
liver failure/double plasma molecular adsorption/plasma exchange/artificial liver/coagula-tion function分类
医药卫生引用本文复制引用
刘倩,陈荣,李明丹,张滢,代梅,徐亚丽,杨平,罗亚文..双重血浆分子吸附序贯血浆置换治疗肝衰竭的临床疗效分析[J].重庆医学,2025,54(3):588-592,5.基金项目
贵州省科技计划项目(黔科合支撑[2021]一般049). （黔科合支撑[2021]一般049）
