重庆医学2025，Vol.54Issue(3)：593-596,4.DOI:10.3969/j.issn.1671-8348.2025.03.006
KL-6在抗MDA5阳性幼年皮肌炎伴肺间质病变患儿血清中的表达研究
Serum KL-6 expression in anti-MDA5-positive juvenile dermatomyositis with interstitial lung disease
摘要
Abstract
Objective To investigate the expression of Krebs Von den Lungen-6(KL-6)in serum of children with anti-melanoma differentiation associated gene 5(MDA5)positive juvenile dermatomyositis(JDM)complicated with interstitial lung disease(ILD)and its clinical significance.Methods Thirty children with anti-MDA5-positive JDM who were admitted to the rheumatology Department of Anhui Children's Hos-pital from January 2020 to December 2023 were selected as the study objects.The children were divided into the ILD group(n=15)and the non-ILD group(n=15)according to whether they had concurrent ILD.Then,the subjects with rapid progressive interstitial lung disease(RP-ILD)in the ILD group were classified as the RP-ILD group(n=5).The expression level of serum KL-6 was detected by chemiluminescence method,and the difference of KL-6 level among the three groups was analyzed,as well as the correlation with clinical indi-cators.Results The level of KL-6 in the RP-ILD group was higher than that in the ILD group(n=10)and the non-ILD group[1 345.22(988.40,1 744.20)U/mL vs.578.00(441.50,845.50)U/mL vs.278.23(145.50,345.20)U/mL],the difference was statistically significant(P＜0.05).The level of KL-6 in the ILD group(n=15)after treatment was significantly lower than that before treatment[(323.89±134.19)U/mL vs.(825.12±320.02)U/mL],the difference was statistically significant(P＜0.05).There was a positive correlation between KL-6 level and serum ferritin level(P＜0.05).Conclusion KL-6 was highly expressed in serum of anti-MDA5 positive JDM children complicated with ILD.关键词
幼年皮肌炎/涎液化糖链抗原-6/抗黑色素瘤分化相关基因蛋白5/间质性肺疾病/快速进展肺间质病变/儿童Key words
juvenile dermatomyositis/Krebs Von den Lungen-6/anti-melanoma differentiation associ-ated gene 5/interstitial lung disease/rapidly progressive pulmonary intestital lesions/child分类
医药卫生引用本文复制引用
高雨彤,陈天平,胡鹏..KL-6在抗MDA5阳性幼年皮肌炎伴肺间质病变患儿血清中的表达研究[J].重庆医学,2025,54(3):593-596,4.基金项目
安徽省自然科学基金面上项目(2108085MH268). （2108085MH268）
