重庆医学2025，Vol.54Issue(3)：606-611,6.DOI:10.3969/j.issn.1671-8348.2025.03.008
复方虎杖方治疗湿热蕴结型代谢相关脂肪性肝病的临床研究
Clinical study on Compound Huzhang Prescription in the treatment of dampness-heat accumulation type metabolic associated fatty liver disease
摘要
Abstract
Objective To investigate the clinical efficacy and mechanism of the Compound Huzhang Prescription in the treatment of dampness-heat accumulation type metabolic-associated fatty liver disease(MAFLD).Methods Eighty MAFLD patients were randomly divided into the treatment group(treated with Compound Huzhang Prescription)and the control group(treated with polyene phosphatidylcholine capsules),with 40 cases in each group.After 3 months of treatment,liver function indicators(ALT,AST,γ-GGT),fast-ing blood glucose(FBG),lipid profiles(TC,TG,HDL-C,LDL-C),hepatic steatosis index(HSI),fibroblast growth factor 21(FGF21),β-Klotho(KBL),homeostasis model assessment of insulin resistance(HOMA-IR)index,and liver fat content measured by MRI were compared between pre-and post-treatment.The efficacy of traditional Chinese medicine(TCM)syndrome was evaluated based on TCM syndrome scores,and the total effective rates of the two groups were compared.Results Two cases dropped out from the treatment group and one from the control group,leaving 38 cases in the treatment group and 39 cases in the control group.The levels of liver function indicators decreased significantly in both groups after treatment compared with those before treatment(P＜0.05).After treatment,TG in the treatment group showed significant decrease com-pared with both pre-treatment level and the control group(P＜0.05).In the control group,there were no significant differences in HSI,FGF21,KBL,HOMA-IR index,or liver fat content before and after treatment(P＞0.05).However,in the treatment group,HSI,FGF21,HOMA-IR,and liver fat content significantly de-creased,while KBL significantly increased after treatment(P＜0.05).Post-treatment,all these indicators in the treatment group showed significant improvement when compared to the control group(P＜0.05).The to-tal effective rate of TCM syndrome efficacy was 81.6%in the treatment group and 46.2%in the control group,with a statistically significant difference between the two groups(P＜0.05).Conclusion The Com-pound Huzhang Prescription is effective in treating MAFLD,and its mechanism is related to alleviating FGF21 resistance.关键词
代谢相关脂肪性肝病/复方虎杖方/成纤维细胞生长因子21/β-KlothoKey words
metabolic associated fatty liver disease/Compound Huzhang Prescription/fibroblast growth factor 21/β-Klotho分类
医药卫生引用本文复制引用
郭晨希,狄红杰,王丹..复方虎杖方治疗湿热蕴结型代谢相关脂肪性肝病的临床研究[J].重庆医学,2025,54(3):606-611,6.基金项目
江苏省中医药科技发展计划项目(YB2020024). （YB2020024）
