重庆医学2025，Vol.54Issue(3)：652-658,7.DOI:10.3969/j.issn.1671-8348.2025.03.017
基于孟德尔随机化探究肠道菌群与弥漫大B细胞淋巴瘤的相关性
Correlation between gut microbiota and diffuse large B-cell lymphoma based on Mendelian randomization
刘娟 1陈明亮 2黄莉评 1尹薇 1林心璐 1李艳秋 1王欣1
作者信息
- 1. 遂宁市中心医院血液科,四川 遂宁 629000
- 2. 遂宁市中心医院消化中心三病区肝胆外科,四川 遂宁 629000
- 折叠
摘要
Abstract
Objective To investigate the causal relationship between gut microbiota and diffuse large B-cell lymphoma(DLBCL).Methods Employed a two-sample bidirectional Mendelian randomization approach,using summary statistics from genome-wide association studies(GWAS)to extract single nucleotide polymor-phisms(SNPs)associated with exposure and outcome as instrumental variables.Exposure instrumental varia-bles(P＜1×10-5)and outcome instrumental variables(P＜5×10-8)were selected based on the P-values of SNPs.Three different Mendelian randomization methods were used to analyze the relationship between gut microbiota and DLBCL,with sensitivity analyses including heterogeneity,pleiotropy,and leave-one-out tests.Results Bilophila(OR=2.043,95%CI:1.279-3.264),Coprobacter(OR=1.371,95%CI:1.035-1.816),Eubacterium eligens group(OR=1.996,95%CI:1.291-3.087)increased the risk of DLBCL.Alistipes(OR=0.588,95%CI:0.359-0.963),Eubacterium eligens group(OR=1.996,95%CI:1.291-3.087),Slackia(OR=0.688,95%CI:0.479-0.988)reduced the risk of DLBCL.Reverse Mendelian randomization a-nalysis failed to reveal any evidence of a causal relationship between DLBCL and the six gut microbiota.Con-clusion There is a causal association between gut microbiota and DLBCL.关键词
弥漫大B细胞淋巴瘤/肠道菌群/孟德尔随机化/单核苷酸多态性/工具变量Key words
diffuse large B-cell lymphoma/gut microbiota/Mendelian randomization/single nucleotide polymorphism/instrumental variable分类
医药卫生引用本文复制引用
刘娟,陈明亮,黄莉评,尹薇,林心璐,李艳秋,王欣..基于孟德尔随机化探究肠道菌群与弥漫大B细胞淋巴瘤的相关性[J].重庆医学,2025,54(3):652-658,7.
