重庆医学2025，Vol.54Issue(3)：738-743,749,7.DOI:10.3969/j.issn.1671-8348.2025.03.031
核糖体蛋白在癌症治疗耐药中的研究进展
Research progress of ribosomal protein in drug resistance in cancer treatment
摘要
Abstract
Ribosomal protein(RP)is an important part of ribosome,which is very important for the assembly and function of ribosome.Recent studies have shown that RP is closely related to the processes of growth,senescence,apoptosis,invasion and drug resistance of tumor cells.The drug resistance of tumors is one of the main reasons for the low cure rate of tumors.RP can affect the drug resistance of tumor cells through a variety of mechanisms,such as changes in signal pathway,epithelial-mesenchymal transformation,cancer stem cells and tumor microenvironment,resulting in a poor prognosis of cancer patients.Ribosome tar-geting therapy is a promising method for the treatment of cancer patients.This review summarizes the mecha-nism of RP and many kinds of cancer drug resistance,provides new ideas for elucidating the mechanism of tumor drug resistance,and then provides new strategies for clinical prevention and reduction of tumor drug re-sistance.关键词
核糖体蛋白/肿瘤耐药/上皮间质转化/信号通路/肿瘤微环境Key words
ribosomal protein/tumor drug resistance/epithelial mesenchymal transformation/signal path/tumor microenvironment分类
医药卫生引用本文复制引用
陈追,揭秋玲,刘明耀,马燕琳..核糖体蛋白在癌症治疗耐药中的研究进展[J].重庆医学,2025,54(3):738-743,749,7.基金项目
国家自然科学基金项目(82360547) （82360547）
海南省重点研发项目(ZDYF2024SHFZ143). （ZDYF2024SHFZ143）
