重庆医学2025，Vol.54Issue(3)：770-774,5.DOI:10.3969/j.issn.1671-8348.2025.03.037
IP3R钙离子通道与呼吸系统相关疾病的研究进展
Research advances in IP3R calcium ion channels and respiratory system-related diseases
摘要
Abstract
The pathogenesis of respiratory diseases such as chronic obstructive pulmonary disease(COPD),asthma,and pulmonary hypertension remains incompletely understood.However,accumulating evi-dence suggests that calcium ion channels play a critical role in these disorders.As a key second messenger,cal-cium ions regulates diverse physiological and pathological processes.Studies indicate that calcium ion homeo-stasis,including their concentration and distribution and spatial distribution is mediated primarily through ino-sitol 1,4,5-trisphosphate receptor(IP3R)channel.Disruption of this homeostasis may contribute to the devel-opment of COPD,asthma,and other respiratory diseases.Nevertheless,the role of IP3R channels in respirato-ry diseases require further investigation.关键词
钙离子/1,4,5-三磷酸肌醇受体/呼吸系统疾病Key words
calcium ion/inositol 1,4,5-trisphosphate receptor/respiratory diseases分类
医药卫生引用本文复制引用
谢欣芸,黄燕,党傲,花荣,张家春,杨朝..IP3R钙离子通道与呼吸系统相关疾病的研究进展[J].重庆医学,2025,54(3):770-774,5.基金项目
国家自然科学基金项目(81560014) （81560014）
江苏省自然科学基金项目(BK20201183) （BK20201183）
江苏省"双创人才"项目(JSSCRC2021568). （JSSCRC2021568）
