重庆医学2025，Vol.54Issue(3)：779-785,7.DOI:10.3969/j.issn.1671-8348.2025.03.039
丙戊酸治疗脊髓损伤作用机制的研究进展
Research progress on mechanism of valproic acid in treatment of spinal cord injury
摘要
Abstract
Spinal cord injury(SCI)can result in varying degrees of spinal motor dysfunction,partial sensory loss and sphincter dysfunction.SCI is divided into two stages:primary injury and secondary injury.The spinal cord cell necrosis during the primary injury period and apoptosis,oxidative stress and autophagy during the secondary injury period lead a large number of cell injury and permanant neurodysfunction.The histone deacetylase(HDAC)plays a key role in regulating the cellular viability and gene transcription.Neuro-dysfunction induced by SCI is associated with transcriptional dysfunction associated with unbalanced levels of protein acetylation.Valproic acid(VPA)is a inhibitor of HDAC and is usually used as an antiepileptic drug in clinic.Studies show that VPA may have the potential to treat the central nervous system diseases.VPA inhib-its HDAC,and then regulates oxidative stress,cellular autophagy,ion imbalance,microglia differentiation and inflammatory response,and plays the neuroprotective effect.This paper reviewed the related molecular mecha-nism of VPA in treating SCI.关键词
脊髓损伤/丙戊酸/信号通路Key words
spinal cord injury/valproic acid/signaling pathways分类
医药卫生引用本文复制引用
柯义兵,郭浩然,王勇平..丙戊酸治疗脊髓损伤作用机制的研究进展[J].重庆医学,2025,54(3):779-785,7.基金项目
甘肃省自然科学基金重点项目(20JR5RA369). （20JR5RA369）
