临床与病理杂志2024，Vol.44Issue(11)：1543-1549,7.DOI:10.11817/j.issn.2095-6959.2024.240988
老年胸腰椎骨折患者围手术期炎症因子水平与术后焦虑、抑郁状态的关系
Relationship between perioperative inflammatory cytokine levels and postoperative anxiety and depression in elderly patients with thoracolumbar fractures
摘要
Abstract
Objective:The central nervous system in elderly patients is often in a state of chronic inflammation.Trauma and surgical injury can further elevate inflammatory cytokine levels,increasing the risk of postoperative anxiety and depression,adversely affecting recovery,prolonging hospital stays,and increasing healthcare costs.This study aims to explore the relationship between perioperative changes in inflammatory cytokine levels and postoperative anxiety and depression in elderly patients with thoracolumbar fractures. Methods:A retrospective analysis was conducted on clinical data from 60 elderly patients who underwent thoracolumbar fracture surgery at the First People's Hospital of Guiyang between December 2022 and December 2023.Inflammatory markers[white blood cells count,neutrophil ratio,serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interferon-gamma(IFN-γ)],as well as scores from the Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS),were compared preoperatively(day 1 after admission)and on postoperative day 1. Results:Preoperatively,patients showed normal levels of white blood cell count,neutrophil ratio,and IFN-γ,while CRP,TNF-α,and IL-6 levels were mildly elevated.Postoperatively,white blood cell count,CRP,TNF-α,and IL-6 levels increased significantly,as did the proportion of patients with anxiety and depression(all P<0.05).Patients with anxiety had significantly higher perioperative levels of white blood cell count,neutrophil ratio,CRP,TNF-α,and IL-6 compared to non-anxious patients(all P<0.05).Similarly,patients with depression had higher neutrophil ratio,CRP,and TNF-α levels than non-depressed patients(all P<0.05).No significant perioperative changes in IFN-γ levels were observed in patients with anxiety or depression(P>0.05). Conclusion:Perioperative changes in inflammatory cytokine levels are closely associated with anxiety and depression in elderly patients with thoracolumbar fractures.As an essential defense mechanism against infection and injury,the inflammatory response may be modulated to help manage perioperative emotional states,providing a clinical basis for improved treatment and enhanced recovery in this patient population.关键词
胸腰椎骨折/老年患者/炎症反应/焦虑/抑郁/围手术期Key words
thoracolumbar fracture/elderly patients/inflammatory response/anxiety/depression/perioperative period引用本文复制引用
肖红利,杨家锋,陈顺宏,齐维林,连学辉..老年胸腰椎骨折患者围手术期炎症因子水平与术后焦虑、抑郁状态的关系[J].临床与病理杂志,2024,44(11):1543-1549,7.基金项目
贵州省卫生健康委科学技术基金(gzwkj2022-366) （gzwkj2022-366）
贵阳市高层次创新型青年卫生人才培养计划项目{[2021]筑卫健科技合同字第8号}.This work was supported by the Science and Technology Fund of Health Committee of Guizhou Province(gzwkj2022-366)and the Guiyang High-level Innovative Youth Health Talents Training Program(2021-08),China. （gzwkj2022-366）
