临床与病理杂志2024，Vol.44Issue(11)：1589-1596,8.DOI:10.11817/j.issn.2095-6959.2024.240622
沉默信息调节因子1在食管癌发生和发展中的作用
Role of silence information regulator factor 1 in the occurrence and development of esophageal cancer
石晓丽 1王成香 1付金妮 1闫麒麟 1蔺成英 1马霖1
作者信息
- 1. 青岛大学附属医院药剂科,山东 青岛 266000
- 折叠
摘要
Abstract
Esophageal cancer is a malignant tumor with a poor prognosis.Current treatment options for esophageal cancer include surgery,chemotherapy,and radiotherapy;however,these approaches are often associated with poor postoperative recovery,high metastatic potential,and the development of drug resistance to chemotherapeutic drugs and radiotherapy.Silence information regulator(SIRT)1 is involved in various cellular biological processes such as DNA repair,cellular senescence,and mitochondrial homeostasis.SIRT1 is the most extensively studied member of the SIRT family.Previous studies have shown that SIRT1 is closely related to the initiation and progression of human cancers.The studies have showed that SIRT1 promoted the occurrence and development of esophageal cancer by promoting the proliferation of esophageal cancer cells,promoting the metastasis of esophageal cancer cells,and inducing autophagy of esophageal cancer cells.Inhibition of the expression of SIRT1 may have the effect of inhibiting the occurrence and development of esophageal cancer in clinical practice,which may provide some ideas for the clinical treatment of esophageal cancer.关键词
沉默信息调节因子1/食管癌/化学治疗/放射治疗/耐药性/细胞自噬Key words
silence information regulation 1/esophageal cancer/chemotherapy/radiotherapy/drug resistance/autophagy引用本文复制引用
石晓丽,王成香,付金妮,闫麒麟,蔺成英,马霖..沉默信息调节因子1在食管癌发生和发展中的作用[J].临床与病理杂志,2024,44(11):1589-1596,8.
