摘要
Abstract
Objective:Mesonephric duct tumor is a rare tumor.This study aims to observe the clinicopathological characteristics of mesonephric duct tumors and to enhance awareness of this tumor and reduce misdiagnosis and missed diagnoses.
Methods:A retrospective analysis of the clinicopathological features of 3 mesonephric duct tumors was conducted,including HE staining,immunohistochemical staining,and periodic acid-Schiff staining.A review of relevant literature and recent advancements was also performed.
Results:All three cases of mesonephric duct tumors occurred in female patients aged 25,42,and 54 years,respectively.The tumors were located in the left broad ligament,right broad ligament,and right mesosalpinx.Microscopically,the tumor cells were tightly arranged in tubular and solid sheet-like patterns,with focal areas showing cribriform structures.A basement membrane-like eosinophilic substance(positive for periodic acid-Schiff staining)was observed around the tubular structures.The tumor cells exhibited mild cytological atypia,with rare mitotic figures.In the solid areas,tumor cells appeared oval,polygonal,or plump spindle-shaped,with the small tubular structures were densely arranged,with cuboidal epithelial cells having clear cytoplasm and round,basally located nuclei.Immunohistochemistry,the tumor cells were positive for cytokeratin-pan(CK-pan),vimentin,inhibin-A,and calretinin,with focal positivity for cluster of differentiation 10(CD10).They were negative for epithelial membrane antigen(EMA),estrogen receptor(ER),progesterone receptor(PR),paired box gene-8(PAX-8),guanine adenine thymine adenine sequence-binding protein-3(GATA-3),and steroidogenic factor-1(SF-1).
Conclusion:Mesonephric duct tumors are neoplasms with low malignant potential.Long-term follow-up is necessary after surgical resection.关键词
中肾管肿瘤/临床病理分析/免疫组织化学/低度恶性潜能/过碘酸希夫染色Key words
mesonephric duct tumor/clinicopathological analysis/immunohistochemistry/low malignant potential/periodic acid-Schiff staining
