赣南医科大学学报2025，Vol.45Issue(2)：117-123,7.DOI:10.3969/j.issn.1001-5779.2025.02.002
核酸感受器DDX60在疾病中的作用研究进展
Advances in the role of the nucleic acid receptor DDX60 in diseases
摘要
Abstract
Nucleic acid receptors have important regulatory roles in innate immunity,inflammation and tumors.The nucleic acid deconjugating enzymes DEAD-box RNA family is the largest family of RNA helicases in mammalian genes.In addition to their deconjugating enzyme functions,some of the deconjugating enzyme molecules also function as nucleic acid receptors that respond to endogenous or exogenous aberrant nucleic acid substances.The understanding of nucleic acid-sensing receptors has also advanced from the maintenance of normal physiological functions to pathogenic defense and to involvement in disease development.Retinoic acid inducible gene-Ⅰ(RIG-Ⅰ)-like receptors,mainly including RIG-Ⅰ and melanoma differentiation-associated gene 5(MDA5),are among the family of deconjugating enzymes identified as nucleic acid re-ceptors involved in the recognition of RNA ligands,and their roles in pathogenic defense,inflammation,and tumors have been extensively investigated.DExD/H-box helicase 60(DDX60)is another molecule that has been identified as hav-ing functional regions similar to those of the deconjugating enzyme molecule of the RIG-Ⅰ-like receptor.In recent years,its role and mechanism in tumor,inflammation,and pathogenic defense have been gradually revealed.This paper sum-marizes and analyses the progress of the research related to DDX60.关键词
DDX60/先天性免疫/病毒防御/炎症/肿瘤Key words
DDX60/Innate immunity/Viral defense/Inflammation/Tumor分类
基础医学引用本文复制引用
席毓灵,隋丽娜,何良梅,刘志平..核酸感受器DDX60在疾病中的作用研究进展[J].赣南医科大学学报,2025,45(2):117-123,7.基金项目
国家自然科学基金项目(31960163,32260191) （31960163,32260191）
井冈学者科研启动金项目(QD202205) （QD202205）
赣南医学院第一附属医院院级科技计划项目(YJZD202007) （YJZD202007）
江西省自然科学基金青年项目(20224BAB216070) （20224BAB216070）
赣南医学院第一附属医院博士启动基金项目(QD202225) （QD202225）
