临床与病理杂志2024，Vol.44Issue(11)：1613-1618,6.DOI:10.11817/j.issn.2095-6959.2024.230429
胃倒置性增生性息肉伴癌变1例并文献复习
Inverted hyperplastic polyp of the stomach with carcinogenesis transformation:A case report and literature review
吴建龙 1郁葱颖 1花海洋 2刘海丽 1王学文 1付昌鸿3
作者信息
- 1. 承德市中心医院病理科,河北 承德 067000
- 2. 承德市中心医院消化内科,河北 承德 067000
- 3. 灵寿县付德保诊所,石家庄 050500
- 折叠
摘要
Abstract
Inverted hyperplastic polyp(IHP)of the stomach is a rare condition,typically presenting without obvious clinical symptoms,making its diagnosis challenging.This study retrospectively analyzes a case of IHP with carcinomatous transformation diagnosed at Chengde Central Hospital,along with a literature review.The patient was a 68-year-old female who was found on endoscopy to have a raised lesion in the gastric fundus,measuring approximately 4 cm×5 cm,with an irregular surface,coarse granular texture,and adherent transparent gelatinous mucus.Histopathological examination revealed lymphocyte and plasma cell infiltration in the mucosal stroma,extensive downward displacement of foveolar epithelium into the muscularis mucosae and submucosa,glandular dilation with polypoid hyperplasia,and focal connection to the mucosal surface.Hyperplastic pyloric glands were present in the submucosa,with some areas exhibiting high-grade dysplasia and focal carcinomatous transformation.Immunohistochemical staining showed positive mucin(MUC)5AC expression in the submucosal gastric foveolar epithelium,while hyperplastic pyloric glands expressed MUC6.Pathological diagnosis:IHP with focal high-grade dysplasia and carcinomatous transformation,with no clear vascular invasion,and no intraepithelial neoplasia was observed in the horizontal or basal margin.IHP is relatively rare in the stomach,and its endoscopic features are non-specific.However,its histopathological characteristics in mucosectomy specimens are distinctive.Pathological diagnosis should be accompanied by differential diagnosis,particularly distinguishing it from deep cystic gastritis and well-differentiated tubular adenocarcinoma.If mucin secretion is observed,differentiation from ectopic intraductal papillary mucinous neoplasm of the pancreas should also be considered.关键词
胃倒置性增生性息肉/癌变/免疫组织化学/临床病理特征/鉴别诊断Key words
gastric inverted hyperplastic polyp/carcinoma/immunohistochemistry/clinicopathological features/differential diagnosis引用本文复制引用
吴建龙,郁葱颖,花海洋,刘海丽,王学文,付昌鸿..胃倒置性增生性息肉伴癌变1例并文献复习[J].临床与病理杂志,2024,44(11):1613-1618,6.
