赣南医科大学学报2025，Vol.45Issue(2)：130-136,153,8.DOI:10.3969/j.issn.1001-5779.2025.02.004
电针调控小胶质细胞相关信号改善神经病理性疼痛的研究
The research progress for the involvement of microglia-related signaling pathways in electroacupuncture modulation of neuropathic pain
摘要
Abstract
Neuropathic pain is caused by injury or disease of the somatosensory nervous system.It is still a public health problem that needs to be solved urgently due to its long course,complex pathophysiological mechanisms and lack of effective treatment.Electroacupuncture(EA),as an effective option for neuropathic pain relief,has been widely used in the world,but its mechanism is still unclear.Previous studies have indicated that the analgesic effect of EA on neuropathic pain is closely related to its modulation of microglia-related signaling pathway.This review will elaborate on the mechanisms and effects of its main signaling pathways(MAPKs,NF-κB,JAK-STAT,PI3K/Akt,cGAS/STING),aiming to provide a scientific basis for further exploring the pathogenesis of neuropathic pain,the analgesic mechanism of EA and attaining new therapeutic targets.关键词
电针/神经病理性疼痛/小胶质细胞/信号通路/神经炎症Key words
Electroacupuncture/Neuropathic pain/Microglia/Signaling pathway/Neuroinflammation分类
中医学引用本文复制引用
孟玲玲,黄诚..电针调控小胶质细胞相关信号改善神经病理性疼痛的研究[J].赣南医科大学学报,2025,45(2):130-136,153,8.基金项目
国家自然科学基金项目(82260233) （82260233）
