分析化学2025，Vol.53Issue(3)：311-327,17.DOI:10.19756/j.issn.0253-3820.251000
脑神经活体原位电化学分析在临床应用中的机遇与挑战
In Vivo Electrochemical Analysis of Brain Neurochemistry:Opportunities and Challenges in Clinical Applications
摘要
Abstract
Neuroscience,a cutting-edge field in interdisciplinary research,consistently draws considerable research interest,of which quantitatively probing the neurochemical dynamics is essential for brain science research.In vivoelectrochemical analysis,featuring with high sensitivity,high spatiotemporal resolution,free from transfection,and designable electrode/solution interfaces,provides important tools for in vivo neurochemicals sensing.Fast scan cyclic voltammetry combined with microelectrodes can not only enable precise detection of dopamine but also is compatible with existing neurosurgical equipment.This offers new opportunities for the clinical application of in vivo electrochemical analysis and paves new avenues for the diagnosis and treatment of neurological diseases.This review summarized recent progress of in vivo electrochemical techniques for brain neurochemistry and addressed key clinical challenges and their potential solutions.关键词
活体电化学分析/临床应用/快速扫描伏安法/脑神经化学/评述Key words
In vivo electrochemistry/Clinical application/Fast scan cyclic voltammetry/Brain neurochemistry/Review引用本文复制引用
李科,魏欢,刘冉,薛亦飞,李丽娟,侯莉娟,毛兰群..脑神经活体原位电化学分析在临床应用中的机遇与挑战[J].分析化学,2025,53(3):311-327,17.基金项目
国家自然科学基金项目(Nos.22134002,22404005)和中国博士后科学基金项目(No.2023M730288)资助. Supported by the National Natural Science Foundation of China(Nos.22134002,22404005)and the China Postdoctoral Science Foundation(No.2023M730288). （Nos.22134002,22404005）
