分析化学2025，Vol.53Issue(3)：328-337,10.DOI:10.19756/j.issn.0253-3820.241369
细胞角蛋白19片段抗原21-1检测方法的研究进展
Research Progress on Detection Methods for Cytokeratin 19 Fragment Antigen 21-1
摘要
Abstract
Cytokeratin 19 fragment antigen 21-1(CYFRA21-1)is a new biomarker which has received much attention in recent years for cancer screening,and has shown great potentials for screening and diagnosis of various cancers,especially non-small cell lung cancer.CYFRA21-1 level in human serum has important clinical significance in the diagnosis,prognosis and treatment of lung cancer.Recently,a variety of detection techniques have been established to effectively enrich the detection technology system of CYFRA21-1,such as enzyme-linked immunosorbent assay,chemiluminescence,fluorescence,immunochromatography,electrochemical method,and surface enhanced Raman spectroscopy,etc.These techniques provide technical support for early diagnosis of lung cancer.However,the research progress of CYFRA21-1 detection methods is rarely reported.In this paper,CYFRA21-1 and its clinical significance were briefly introduced,and the progress of detection technology in recent ten years was reviewed,which was expected to provide reference for developing more sensitive,accurate,fast and convenient detection methods.关键词
细胞角蛋白19片段抗原21-1/肿瘤标志物/检测方法/肺癌/评述Key words
Cytokeratin 19 fragment antigen 21-1/Tumor markers/Detection methods/Lung cancer/Review引用本文复制引用
董嘉晖,沈丽悦,祀吉豪,俞晓平,彭涛..细胞角蛋白19片段抗原21-1检测方法的研究进展[J].分析化学,2025,53(3):328-337,10.基金项目
国家重点研发计划项目(No.2022YFF0608402)资助. Supported by the National Key Research and Development Project of China(No.2022YFF0608402). （No.2022YFF0608402）
