口腔疾病防治2025，Vol.33Issue(4)：320-327,8.DOI:10.12016/j.issn.2096-1456.202440097
处理后牙本质基质在活髓保存领域中的研究进展
Research progress of treated dentin matrix in vital pulp therapy
摘要
Abstract
There has been an increase in research interest and application of treated dentin matrix(TDM)in vital pulp therapy(VPT)in recent years.TDM has excellent biocompatibility and contains transforming growth factor-β,bone morphogenetic protein 2,and other odontogenesis/osteogenesis-related proteins and factors that promote odontogenic dif-ferentiation of dental stem cells.TDM-based products,ranging from powders and pastes to injectable composite gels and gel scaffolds,have gained increasing consensus for their ability to induce dentin-like tissue regeneration.Animal and clinical studies found that TDM has significant advantages over traditional pulp capping materials,as it can form well-organized layers of odontoblast-like cells and uniform dentinal tubule structures.Future challenges of TDM in VPT ap-plication are primarily focused on improving mechanical properties and addressing potential immune rejection issues with heterologous material use.Additionally,further studies should be conducted on the odontogenetic pathway mecha-nism of TDM and the immune regulatory capabilities of xenogeneic dentin matrix materials.Utilizing TDM to construct tissue engineering scaffolds for VPT presents a promising strategy.This article reviews the structure and biological prop-erties of TDM and related materials,thoroughly examines their progresses in the field of VPT,and discusses their cur-rent challenges as well as future research directions.关键词
活髓保存治疗/生物材料/处理后牙本质基质/脱矿牙本质基质/转化生长因子-β/骨形态发生蛋白2/牙本质再生/牙髓-牙本质复合体/直接盖髓/牙源性干细胞Key words
vital pulp therapy/biomaterial/treated dentin matrix/demineralized dentin matrix/transforming growth factor-β/bone morphogenetic protein 2/dentin regeneration/dentin-pulp complex/direct pulp capping/dental stem cells分类
口腔医学引用本文复制引用
戴雨果,郭维华..处理后牙本质基质在活髓保存领域中的研究进展[J].口腔疾病防治,2025,33(4):320-327,8.基金项目
国家自然科学基金资助项目(82270958) （82270958）
四川省创新人才项目(2022JDRC0043) （2022JDRC0043）
云南省重大科技项目(202302AA310038) This study was supported by the grants from the Nature Science Foundation of China(No.82270958) （202302AA310038）
the Innovative Talent Project in Sichuan Province(No.2022JDRC0043),the Major Science and Technology Projects in Yunnan Prov-ince(No.202302AA310038). （No.2022JDRC0043）
