口腔疾病防治2025，Vol.33Issue(4)：328-335,8.DOI:10.12016/j.issn.2096-1456.202440225
群体感应在变异链球菌与白色念珠菌致龋作用中的研究进展
Research progress on quorum sensing in the caries-causing effects of Streptococcus mutans and Candida albi-cans
摘要
Abstract
Dental caries is a major disease that seriously endangers human oral health.Dental plaque biofilm com-posed of many microorganisms is the primary factor of dental caries.Inhibiting biofilm formation has become the focus of research on the prevention and treatment of dental caries.Streptococcus mutans and Candida albicans,as common pathogenic bacteria in the oral cavity,are closely related to the occurrence of dental caries.The interaction between the two can lead to the rapid onset of dental caries.In recent years,many studies have found that Candida albicans pro-motes the occurrence of caries by interacting with Streptococcus mutans,including physical adhesion,promoting the pro-duction of exopolysaccharides(EPS),reducing the pH of the microecological environment,forming a highly cariogenic acidic environment,and secreting quorum sensing molecules to trigger quorum sensing.As a communication mechanism between microorganisms,the quorum sensing system mainly includes three main types:autoinducing peptide(AIP)sys-tem,autoinducer-2(AI-2)system,and Acyl-homoserine lactone(AHL)system.At present,quorum sensing has been shown to promote the occurrence of diseases by activating the expression of microbial pathogenicity-related genes,pro-moting EPS synthesis and biofilm formation.The CSP-ComDE and ComRS quorum sensing systems of Streptococcus mu-tans allow the bacteria to survive and cause disease in extreme environments that are unfavorable for survival,while the quorum sensing system of Candida albicans is mainly mediated by farnesol,which has a negative regulatory effect on the yeast-hyphae transformation of Candida albicans.Studying the quorum sensing phenomenon of the two bacteria is helpful to understand the etiology of caries.In recent years,many studies have reported the use of quorum sensing inhib-itors in anti-microbial applications.The study of microbial quorum sensing systems and inhibitors will help the preven-tion and treatment of caries.With the increasing interest in biofilm-related research,and a new method for in-depth study of the biofilm formation process and quorum sensing behavior using microfluidic and chip laboratory technology is proposed.The author summarizes the cariogenic effects,the quorum sensing system and quorum sensing inhibitors of Streptococcus mutans and Candida albicans.关键词
龋病/龋病防治/生物膜/变异链球菌/白色念珠菌/群体感应/群体感应抑制剂/跨界作用Key words
dental caries/caries prevention/biofilm/Streptococcus mutans/Candida albicans/quorum sensing/quorum sensing inhibitors/cross field分类
口腔医学引用本文复制引用
廖桢桢,李文秀,梁燕..群体感应在变异链球菌与白色念珠菌致龋作用中的研究进展[J].口腔疾病防治,2025,33(4):328-335,8.基金项目
贵州省科技厅基金(黔科合基础-ZK[2024]一般252) This study was supported by the grants from Guizhou Provincial Science and Technology De-partment Fund(Guizhou Science and Technology Foundation-ZK[2024]General 252). （黔科合基础-ZK[2024]一般252）
