口腔疾病防治2025，Vol.33Issue(4)：336-343,8.DOI:10.12016/j.issn.2096-1456.202440116
铁死亡在牙周炎发生发展过程中的研究进展
Research progress of ferroptosis in the occurrence and development of periodontitis
摘要
Abstract
Periodontal disease is a chronic infectious disease characterized by chronic inflammation and progressive destruction of the periodontal tissue.Ferroptosis,an iron-dependent form of programmed cell death,is primarily charac-terized by altered iron homeostasis,weak antioxidant defense,and accumulation of lipid peroxides and plays an impor-tant role in a variety of diseases.Recent research has shown the correlation between ferroptosis and the occurrence and development of periodontal disease.Through in-depth research of relevant literature on periodontal ligament fibroblasts,periodontal ligament stem cells,human immortalized oral epithelial cells,human gingival fibroblasts,dental pulp stem cells,MLOY4 cells,mouse mandibular osteoblast,and macrophages,we found that ferroptosis is widely suppressed in periodontal disease.This phenomenon is primarily related to lipid metabolism,iron metabolism,cysteine/glutamate transporter system xc-/glutathione/glutathione peroxidase 4,nicotinamide adenine dinucleotide phosphate/ferroptosis sup-pressor protein 1/coenzyme Q10,kelch-like ECH-associated protein-1/nuclear factor E2 related factor 2,and p53.Cur-rent research indicates that ferroptosis plays an important role in regulating the destruction of periodontal soft and hard tissues,inflammatory response,and periodontopathogen-induced progression of systemic diseases.Although there are several studies on the mechanism of ferroptosis in periodontal disease,there are many uncertainties in the application of ferroptosis in periodontal therapy.Therefore,further studies are required to explore and develop ferroptosis-related drugs for the treatment of periodontal disease.关键词
牙周炎/铁死亡/活性氧/炎症反应/全身性疾病/牙周病原菌/铁离子代谢/脂质代谢/氨基酸抗氧化系统/谷胱甘肽过氧化物酶4/铁死亡抑制蛋白1Key words
periodontitis/ferroptosis/reactive oxygen species/inflammatory response/systemic disease/periodontal pathogen/iron metabolism/lipid metabolism/amino-acid antioxidant system/glutathione peroxidase 4/ferroptosis suppressor protein 1分类
口腔医学引用本文复制引用
孙瑞蔓,秦旭,朱光勋..铁死亡在牙周炎发生发展过程中的研究进展[J].口腔疾病防治,2025,33(4):336-343,8.基金项目
湖北省自然科学基金(2023AFB653 （）
2023AFB765) This study was supported by the grants from Natural Science Foundation of Hubei Province of China(No.2023AFB653)and Natural Science Foundation of Hubei Province of China(No.2023AFB765). （No.2023AFB653）
