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Pivotal roles of biglycan and decorin in regulating bone mass,water retention,and bone toughness

Rui Hua Yan Han Qingwen Ni Roberto J.Fajardo Renato V.Iozzo Rafay Ahmed Jeffry S.Nyman Xiaodu Wang Jean X.Jiang

骨研究（英文版）2025，Vol.13Issue(1)：48-61,14.

骨研究（英文版）2025，Vol.13Issue(1)：48-61,14.DOI:10.1038/s41413-024-00380-2

Pivotal roles of biglycan and decorin in regulating bone mass,water retention,and bone toughness

Rui Hua ¹Yan Han ²Qingwen Ni ³Roberto J.Fajardo ⁴Renato V.Iozzo ⁵Rafay Ahmed ⁶Jeffry S.Nyman ⁷Xiaodu Wang ²Jean X.Jiang¹

作者信息

1. Department of Biochemistry and Structural Biology,University of Texas Health Science Center,San Antonio,TX,USA
2. Department of Mechanical Engineering,University of Texas at San Antonio,San Antonio,TX,USA
3. Department of Physics,Texas A&M International University,Laredo,TX,USA
4. School of Osteopathic Medicine,University of the Incarnate Word,San Antonio,TX,USA
5. Department of Pathology&Genomic Medicine,Sidney Kimmel Medical Collage,Thomas Jefferson University,Philadelphia,PA,USA
6. Department of Orthopaedic Surgery,Vanderbilt University Medical Center,Nashville,TN,USA
7. Department of Orthopaedic Surgery,Vanderbilt University Medical Center,Nashville,TN,USA||United States Department of Veterans Affairs,Tennessee Valley Healthcare System,Nashville,TN,USA
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摘要

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Rui Hua,Yan Han,Qingwen Ni,Roberto J.Fajardo,Renato V.Iozzo,Rafay Ahmed,Jeffry S.Nyman,Xiaodu Wang,Jean X.Jiang..Pivotal roles of biglycan and decorin in regulating bone mass,water retention,and bone toughness[J].骨研究（英文版）,2025,13(1):48-61,14.

基金项目

The Bgn KO mice were generously provided by Marian F.Young at National Institutes of Health.We acknowledge Xuewei Wang,Dr.Jingruo Zhang,and Lidan Zhang for their technical assistance.The authors declare no competing financial interests.This work was supported by the National Institutes of Health(NIH)Grants:RO1 AR076190(to X.W and J.X.J)and Welch Foundation grant:AQ-1507(to J.X.J.). （NIH）

骨研究（英文版）

ISSN：2095-4700

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