骨研究（英文版）2025，Vol.13Issue(1)：75-90,16.DOI:10.1038/s41413-024-00382-0
Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice,monkeys and humans
Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice,monkeys and humans
Shishu Huang 1Xiaojun Shi 2Qinshen Hu 2Yong Nie 2Zhong Zhang 2Zeyu Luo 2Duan Wang 2Zhihe Zhao 3Lingli Li 4Guanglin Wang 2Liping Wang 5Dashuang Gao 6Zongke Zhou 2Di Chen 7Fan Yang 8Zhenxia Li 9Hongchen He 10Xi Yu 10Xuanhe You 2Diwei Wu 2Ze Du 2Jiancheng Zeng2
作者信息
- 1. Department of Orthopedics Surgery and Orthopedic Research Institute,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu,China||The Guangdong Provincial Key Laboratory of Brain Connectome and Behavior,CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences||Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen,China
- 2. Department of Orthopedics Surgery and Orthopedic Research Institute,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu,China
- 3. State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu,China
- 4. Department of Nursing,West China Hospital,Sichuan University,Chengdu,China
- 5. The Guangdong Provincial Key Laboratory of Brain Connectome and Behavior,CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences||Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen,China
- 6. The Guangdong Provincial Key Laboratory of Brain Connectome and Behavior,CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences||Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen,China||University of Chinese Academy of Sciences,Beijing,China||The seventh Clinical Medical School of Guangzhou University of Chinese Medicine,Bao'an District TCM Hospital,Shenzhen,Guangdong,China
- 7. Research Center for Computer-aided Drug Discovery,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China
- 8. The Guangdong Provincial Key Laboratory of Brain Connectome and Behavior,CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences||Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen,China||University of Chinese Academy of Sciences,Beijing,China
- 9. Department of Orthodontics,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine||College of Stomatology,Shanghai Jiao Tong University||National Center for Stomatology||National Clinical Research Center for Oral Diseases,Shanghai,China
- 10. Rehabilitation Medicine Center,West China Hospital,Sichuan University,Chengdu,China
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Shishu Huang,Xiaojun Shi,Qinshen Hu,Yong Nie,Zhong Zhang,Zeyu Luo,Duan Wang,Zhihe Zhao,Lingli Li,Guanglin Wang,Liping Wang,Dashuang Gao,Zongke Zhou,Di Chen,Fan Yang,Zhenxia Li,Hongchen He,Xi Yu,Xuanhe You,Diwei Wu,Ze Du,Jiancheng Zeng..Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice,monkeys and humans[J].骨研究（英文版）,2025,13(1):75-90,16.基金项目
We are grateful to all the members of the Huang and Yang laboratories for providing comments and advice throughout the project.We are grateful to Jiazhuang Xu of Sichuan University.This project was partly supported by the National Key R&D Program of China(2023YFA1801200,2023YFA1801202),the Major Program of the National Natural Science Foundation of China(T2394532),the National Natural Science Foundation of China(82072489) （2023YFA1801200,2023YFA1801202）
The Foundation of Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(NYKFKT2019007) （NYKFKT2019007）
Shenzhen Medical Research Fund(B2302011) （B2302011）
The Sanming Project of Medicine in Shenzhen(SZZYSM202311013) （SZZYSM202311013）
The China Postdoctoral Science Foundational,2023M743679.Shenzhen Science and Technology Research Funding(JCYJ20220818101414032).Key Research Project of Science&Technology Department of Sichuan Province,China(2024YFFK0041). （JCYJ20220818101414032）
